糖肾康颗粒治疗糖尿病肾病气阴两虚兼血瘀证30例临床观察  

Clinical effect of Tangshenkang granules in treatment of diabetic kidney disease with deficiency of both Qi and Yin and blood stasis syndrome:An analysis of 30 cases

作　　者：王吉磊[1] 刘世宾[1] 宿晶[1] 郑汝吏 司廷林[1] 高建东[1] WANG Jilei;LIU Shibin;SU Jing;ZHENG Ruli;SI Tinglin;GAO Jiandong(The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250001,Shandong,China)

机构地区：[1]山东中医药大学第二附属医院,山东济南250001

出　　处：《湖南中医杂志》2024年第4期14-17,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：山东省齐鲁医派中医学术流派传承项目([2021]45号);山东省中医药科技项目(2021Q102)。

摘　　要：目的:探讨糖肾康颗粒治疗糖尿病肾病(DKD)Ⅲ期气阴两虚兼血瘀证的临床疗效。方法:收集糖尿病肾病Ⅲ期气阴两虚兼血瘀证患者60例,随机分为治疗组和对照组,每组各30例。对照组采用西医常规治疗,治疗组在对照组的基础上加服糖肾康颗粒,2组均治疗8周。观察2组治疗前后中医证候积分、空腹血糖(FPG)、餐后2h血糖(2hPBG)、尿微量白蛋白/肌酐比值(ACR)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、胱抑素C(Cys-C)水平以及不良反应发生情况。结果:总有效率治疗组为86.67%(26/30),明显高于对照组的53.33%(16/30);且治疗组尿ACR、hs-CRP、IL-6、Cys-C水平均低于对照组(P<0.05);2组不良发生率均为9.99%(3/30)。结论:糖肾康颗粒治疗DKD气阴两虚兼血瘀证的疗效颇佳,可有效减轻蛋白尿,改善肾功能,降低炎症因子水平。Objective:To investigate the clinical effect of Tangshenkang granules in the treatment of diabetic kidney with stageⅢdisease(DKD)with deficiency of both Qi and Yin and blood stasis syndrome.Methods:A total of 60 patients with stage III DKD with deficiency of both Qi and Yin and blood stasis syndrome were collected and randomly divided into treatment group and control group,with 30 patients in each group.The patients in the control group received conventional Western medicine treatment,and those in the treatment group received Tangshenkang granules in addition to the treatment in the control group;the course of treatment was 8 weeks for both groups.The two groups were compared in terms of traditional Chinese medicine(TCM)syndrome score,fasting plasma glucose,2-hour postprandial blood glucose,urinary microalbumin/creatinine ratio(ACR),highsensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),cystatin C(Cys-C),and adverse reactions.Results:The treatment group had a significantly higher overall response rate than the control group[86.67%(26/30)vs 53.33%(16/30),P<0.05].Compared with the control group,the treatment group had a significantly lower levels of ACR,hs-CRP,IL-6,and Cys-C(P<0.05).The adverse reaction rates in both qroups were 9.99%(16/30).Conclusion:Tangshenkang granules have a marked clinical effect in the treatment of DKD with deficiency of both Qi and Yin and blood stasis syndrome and can effectively alleviate proteinuria,improve renal function,and reduce the levels of inflammatory factors.

关 键 词：糖尿病肾病 Ⅲ期 气阴两虚兼血瘀证 糖肾康颗粒 

分 类 号：R259.872[医药卫生—中西医结合]