运动改善2型糖尿病所致心肌并发症的保护效应与分子机制研究进展  

Protective Effects and Molecular Mechanisms of Exercise on Reducing Myocardial Complications Induced by type 2 Diabetes Mellitus

作　　者：朱新燕 刘菁菁 张媛[1] 陆矫 ZHU Xinyan;LIU Jingjing;ZHANG Yuan;无(School of Sports and Health,Nanjing Sport Institute,Nanjing Jiangsu,210014,China;Jiangsu Collaborative Innovation Center for Sport and Health Project,Nanjing Jiangsu,210014,China.)

机构地区：[1]南京体育学院运动健康学院,江苏南京210014 [2]江苏省“运动与健康”工程协同创新中心,江苏南京210014

出　　处：《四川体育科学》2024年第3期23-29,共7页Sichuan Sports Science

基　　金：国家自然科学基金青年项目(32000839);江苏省高等学校大学生创新创业训练计划项目(202110330031Y);江苏省运动与健康工程协同创新青年扶持项目(JSCIC-YP21003);江苏省自然科学基金面上项目:(BK20191473)。

摘　　要：糖尿病心肌病是2型糖尿病致死的重要原因之一,其发生发展与2型糖尿病引起的机体糖脂代谢紊乱与胰岛素抵抗密切相关。运动是防治2型糖尿病重要的非药物干预手段,其诱导的机体内源性保护效应是促进心血管健康的重要机制。本文通过文献研究,对早期2型糖尿病诱导心肌组织重塑的机制进行总结,并对运动减轻糖尿病心肌并发症的保护效应与分子机制进行综述。Diabetic cardiomyopathy is one of the important causes of death in type 2 diabetes mellitus,which was closely related to the glycolipid metabolism disorder and insulin resistance.Exercise is an important non-drug treatment for the prevention and treatment of type 2 diabetes.The mechanism under exercise-induced cardiovascular protection is probably related to the endogenous protective effect.The researches on mechanisms of early myocardial remodeling induced by type 2 diabetes were summed up in this article.Meanwhile,we summarized the protective effects and molecular mechanisms of exercise-induced cardioprotection of diabetic cardiomyopathy.

关 键 词：糖尿病心肌病 运动 2型糖尿病 心肌重塑 分子机制 

分 类 号：G80-051[文化科学—运动人体科学]