脂联素对动物免疫细胞的影响  

Effects of adiponectin on immune cells in animals

作　　者：姚泽龙 邢晓钰 李嘉鑫 刘聪 孔燕明 魏诗音 曹中赞[1] 栾新红[1] YAO Zelong;XING Xiaoyu;LI Jiaxin;LIU Cong;KONG Yanming;WEI Shiyin;CAO Zhongzan;LUAN Xinhong(College of Animal Science and Veterinary Medicine,Shenyang Agricultural University,Shenyang 110161,China)

机构地区：[1]沈阳农业大学动物科学与医学学院,沈阳110161

出　　处：《黑龙江畜牧兽医》2024年第9期18-21,共4页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(32272953,32072810)。

摘　　要：脂联素作为一种重要的脂肪因子,通过调节免疫细胞的数量、功能、细胞信号通路和炎症反应参与免疫系统稳态、疾病发展等重要过程。脂联素参与调节免疫细胞的凋亡和增殖,对免疫细胞生命周期的调节起到重要作用。体内脂联素水平升高可引起单核细胞、巨噬细胞和树突状细胞数量的增加,促进T淋巴细胞和B淋巴细胞的分化和增殖。脂联素还能够调节免疫细胞的表面标志物CD80、CD86和CD40等表达,通过影响免疫细胞的数量和功能影响整个免疫系统的稳态。此外,脂联素可以通过激活PI3K/Akt信号通路和AMPK信号通路来调节免疫细胞的活化和增殖,通过抑制核因子κB(NF-κB)信号通路,减轻免疫细胞的炎症反应。脂联素不仅在正常免疫调节中发挥重要作用,而且在疾病的免疫调节中也发挥关键作用。文章综述了脂联素通过影响动物免疫细胞参与免疫机能调节的研究进展,以期为探讨脂联素调节免疫系统的分子机制、寻找新的免疫相关疾病治疗靶点提供理论参考。Adiponectin,as an important adipokine,participates in the homeostasis of the immune system,disease development and other important processes by regulating the number,function,cell signaling pathway and inflammatory response of immune cells.Adiponectin is involved in regulating the apoptosis and proliferation of immune cells and plays an important role in the life cycle regulation of immune cells.Elevated adiponectin levels in vivo can increase the number of monocytes,macrophages and dendritic cells,and promote the differentiation and proliferation of T cells and B cells.Adiponectin can also regulate the expression of surface markers CD80,CD86 and CD40 of immune cells,and affect the homeostasis of the whole immune system by affecting the number and function of immune cells.In addition,adiponectin can regulate the activation and proliferation of immune cells by activating PI3K/Akt signaling pathway and AMPK signaling pathway.Adiponectin can also inhibit the activation of NF-κB signaling pathway and reduce the inflammatory response of immune cells.Adiponectin not only plays an important role in normal immune regulation,but also plays a key role in immune regulation of diseases.In this paper,the progress of adiponectin's involvement in the regulation of immune function by influencing animal immune cells was reviewed,in order to provide theoretical reference for exploring the molecular mechanism of adiponectin regulation of the immune system and finding new therapeutic targets for immune-related diseases.

关 键 词：脂联素 免疫细胞 免疫调节 脂联素受体 炎症 

分 类 号：S852.2[农业科学—基础兽医学]