外周血NLR、PLR、MPVLR联合CRP在儿童难治性肺炎支原体肺炎中的预测价值  

The predictive value of NLR,PLR,MPVLR combined with CRP in peripheral blood in children with refractory Mycoplasma pneumoniae pneumonia

作　　者：王娟 申翠平 WANG Juan;SHEN Cuiping(Department of Pediatrics,Changzhi People′s Hospital,Changzhi,Shanxi 046000,China)

机构地区：[1]山西省长治市人民医院儿科,山西长治046000

出　　处：《检验医学与临床》2024年第11期1631-1635,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨肺炎支原体肺炎(MPP)患儿外周血中性粒细胞计数(NEU)/淋巴细胞计数(LYM)比值(NLR)、血小板计数(PLT)/LYM比值(PLR)、平均血小板体积(MPV)/LYM比值(MPVLR)联合C反应蛋白(CRP)在儿童难治性肺炎支原体肺炎(RMPP)中的预测价值。方法选取2021年6月至2022年6月在山西省长治市人民医院儿科住院的427例MPP患儿作为研究对象,将常规MPP患儿分为GMPP组(341例),RMPP患儿分为RMPP组(86例)。比较两组住院时间、白细胞计数、NEU、LYM、PLT、MPV、NLR、PLR、MPVLR及乳酸脱氢酶(LDH)、红细胞沉降率、CRP、谷丙转氨酶(ALT)、血红蛋白水平。采用多因素Logistic回归分析MPP患儿进展为RMPP的危险因素。绘制受试者工作特征(ROC)曲线分析NLR、PLR、MPVLR、CRP在MPP患儿进展为RMPP中的预测价值。结果两组NEU、LYM、NLR、PLT、PLR、MPVLR、CRP、LDH、ALT水平、住院时间比较,差异均有统计学意义(P<0.05)。NLR、PLR、MPVLR、CRP水平升高是MPP患儿进展为RMPP的危险因素(P<0.05)。ROC曲线分析结果显示,NLR、PLR、MPVLR、CRP单独预测MMP患儿进展为RMPP的曲线下面积(AUC)分别为0.663、0.601、0.646、0.724。NLR联合CRP、PLR联合CRP、MPVLR联合CRP预测MMP患儿进展为RMPP的AUC分别为0.740、0.729、0.723。结论外周血NLR、PLR、MPVLR分别联合CRP在MPP患儿进展为RMPP中的预测价值比单项指标预测更高。Objective To investigate the predictive value of neutrophil(NEU)/lymphocyte(LYM)ratio(NLR),platelet(PLT)/LYM ratio(PLR),mean platelet volume(MPV)/LYM ratio(MPVLR)combined with C-reactive protein(CRP)in children with Mycoplasma pneumoniae pneumonia(MPP)in refractory Mycoplasma pneumoniae pneumonia(RMPP).Methods A total of 427 children with MPP who were hospitalized in the Department of Pediatrics,Changzhi People′s Hospital from June 2021 to June 2022 were selected as the research objects.Children with conventional MPP were divided into GMPP group(341 cases)and children with RMPP were divided into RMPP group(86 cases).The length of hospital stay,white blood cell count,NEU,LYM,PLT,MPV,NLR,PLR,MPVLR,lactate dehydrogenase(LDH),erythrocyte sedimentation rate,CRP,alanine aminotransferase(ALT)and hemoglobin levels were compared between the two groups.Multivariate Logistic regression was used to analyze the risk factors for the progression of MPP to RMPP.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of NLR,PLR,MPVLR and CRP of MPP to RMPP in children.Results NEU,LYM,NLR,PLT,PLR,MPVLR,CRP,LDH,ALT levels and hospital stay were significantly different between the two groups(P<0.05).The increased NLR,PLR,MPVLR and CRP level were risk factors for the progression of MPP to RMPP in children(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of NLR,PLR,MPVLR and CRP alone in predicting the progression of MMP to RMPP was 0.663,0.601,0.646 and 0.724 respectively.The AUC of NLR combined with CRP,PLR combined with CRP and MPVLR combined with CRP in predicting the progression to RMPP in children with MMP were 0.740,0.729 and 0.723 respectively.Conclusion The predictive value of NLR,PLR,MPVLR combined with CRPof MPP to RMPP in children is higher than that of each index alone.

关 键 词：肺炎支原体肺炎 难治性肺炎支原体肺炎 中性粒细胞计数/淋巴细胞计数比值 血小板计数/淋巴细胞计数比值 平均血小板体积/淋巴细胞计数比值 C反应蛋白 

分 类 号：R725.6[医药卫生—儿科] R446.1[医药卫生—临床医学]