Rhupus综合征合并急性乙型病毒性肝炎一例  

Rhupus syndrome complicated with acute viral hepatitis type B:a case report

作　　者：欧阳志明[1] 杨迎 潘婕 邹耀威 贾霈雯 戴冽[1] OUYANG Zhi-ming;YANG Ying;PAN Jie;ZOU Yao-wei;JIA Pei-wen;DAI Lie(Department of Rheumatology and Immunology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong,CHINA)

机构地区：[1]中山大学孙逸仙纪念医院风湿免疫科,广东广州510120

出　　处：《海南医学》2024年第11期1658-1660,共3页Hainan Medical Journal

基　　金：国家自然科学基金(编号:82171780、81971527);广东省基础与应用基础研究基金(编号:2022A1515010524)。

摘　　要：本文报道一例既往乙肝五项定量全阴的Rhupus综合征患者在甲氨蝶呤+来氟米特+羟氯喹治疗期间发现性伴侣为慢性乙型肝炎病毒(HBV)感染患者,及时行HBV血清标志物及肝功能检测,发现自己已感染HBV,继而出现急性乙型病毒性肝炎,予保肝对症支持治疗及抗病毒等治疗,复查HBsAg转阴。This article reported a case of Rhupus syndrome patient who was negative for Hepatitis B serologictest in the past but had been infected with HBV from her sexual partner later.During the treatment with methotrexate,leflunomide and hydroxychloroquine,she found that her sexual partner had chronic hepatitis B virus(HBV)infection.She promptly tested HBV serum markers and liver function and found out that she had been infected with HBV,and then developed acute hepatitis B.After symptomatic and supportive treatment of liver protection and antiviral treatment,HBsAg was negative in reexamination.

关 键 词：风湿性疾病 免疫抑制治疗 乙型肝炎病毒 

分 类 号：R512.62[医药卫生—内科学]