麻射安金丸联合噻托溴铵吸入粉雾剂治疗痰热壅肺型AECOPD的临床效果  

The clinical efficacy of Mashe Anjin Pills combined with tiotropium bromide powder for inhalation in treating phlegm-heat obstructing lung type AECOPD

作　　者：邓敬华 尚艳花 张晓阳 马真 王玉栋 DENG Jinghua;SHANG Yanhua;ZHANG Xiaoyang;MA Zhen;WANG Yudong(Hengshui Hospital of Traditional Chinese Medicine,Hebei Province,Hengshui 053000,China)

机构地区：[1]河北省衡水市中医医院,053000

出　　处：《临床合理用药杂志》2024年第14期15-18,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：河北省中医药管理局中医药科研项计划项目(2022274)。

摘　　要：目的观察麻射安金丸联合噻托溴铵吸入粉雾剂治疗痰热壅肺型慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床效果。方法选取2021年8月—2022年8月衡水市中医医院收治的痰热壅肺型AECOPD患者共120例,根据随机数字表法分为观察组与对照组,每组60例。在常规治疗基础上,对照组予噻托溴铵吸入粉雾剂吸入治疗,观察组在对照组基础上联合麻射安金丸治疗,2组均治疗2周。比较2组患者治疗效果,治疗前后肺功能指标[第1秒用力呼气容积(FEV 1)、用力肺活量(FVC)、及FEV 1/FVC]、呼吸困难程度[COPD患者自我评估测试(CAT)评分、改良版英国医学研究委员会呼吸困难问卷(mMRC)评分]、血清炎性因子[白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]及不良反应。结果观察组患者治疗总有效率为96.67%,高于对照组的81.67%(χ^(2)=6.988,P=0.008);治疗2周后,2组FEV 1、FVC及FEV 1/FVC均较治疗前提升,CAT、mMRC评分与血清IL-8、TNF-α、CRP水平均较治疗前下降,且观察组提升/下降幅度大于对照组(P均<0.01);观察组与对照组不良反应总发生率比较差异无统计学意义(11.67%vs.6.67%,χ^(2)=0.901,P=0.343)。结论麻射安金丸联合噻托溴铵吸入粉雾剂在痰热壅肺型AECOPD患者中的治疗效果肯定,可改善患者肺功能,缓解呼吸困难症状与炎性反应程度,且安全性较高。Objective To observe the clinical efficacy of Mashe Anjin Pills combined with Tiotropium Bromide Powder for Inhalation in treating phlegm-heat obstructing lung type acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 120 patients diagnosed with phlegm-heat obstructing lung type AECOPD admitted to Hengshui Hospital of Traditional Chinese Medicine from August 2021 to August 2022 were selected.They were divided into an observation group and a control group,with 60 cases in each group,according to a random number table method.On the basis of conventional treatment,the control group received inhalation therapy with tiotropium bromide inhalation powder,while the observation group received combined treatment with Mashe Anjin Pills in addition to the treatment received by the control group.Both groups were treated for 2 weeks.The treatment effects of the two groups and changes in pulmonary function indicators(FEV 1,FVC,and FEV 1/FVC),severity of breathlessness(CAT score,mMRC score),serum inflammatory factors(IL-8,TNF-α,CRP)before and after treatment,as well as adverse reactions in both groups were compared.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than that in the control group(81.67%)(χ^(2)=6.988,P=0.008);After 2 weeks of treatment,both groups showed improvements in FEV 1,FVC,and FEV 1/FVC compared to before treatment.CAT scores,mMRC scores,and serum levels of IL-8,TNF-α,and CRP decreased compared to before treatment,with greater improvements/decreases observed in the observation group than in the control group(All P<0.01);There was no statistically significant difference in the total incidence of adverse reactions between the observation group and the control group(11.67%vs.8.33%,χ^(2)=0.901,P=0.343).Conclusion The therapeutic effect of Mashe Anjin Pills combined with Tiotropium Bromide Powder for Inhalation in patients with phlegm-heat obstructing lung type AECOPD is commendable.It can improve patients′pulmonary function,

关 键 词：慢性阻塞性肺疾病 急性加重期 痰热壅肺 麻射安金丸 噻托溴铵吸入粉雾剂 

分 类 号：R563.9[医药卫生—呼吸系统]