中药通过细胞外信号调节激酶信号通路调控胃癌的研究进展  

Research Progress in the Regulation of Gastric Cancer by Traditional Chinese Medicine Through Extracellular Signal-regulated Kinase Signaling Pathway

作　　者：赵颖异 吕星 谭雅兰 韩永光[1] ZHAO Yingyi;LYU Xing;TAN Yalan;HAN Yongguang(Colleges of Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,郑州450046

出　　处：《世界中医药》2024年第7期1043-1048,1055,共7页World Chinese Medicine

基　　金：国家重点研发计划项目(2019YFC1708802);河南省高等学校青年骨干教师培养计划项目(2020GGJS111);河南张仲景方药与免疫调节重点实验室开放课题(KFKT202002);河南省大学生创新创业计划(S202110471030);河南中医药大学2021年度研究生科研创新能力提升计划(2021KYCX053)。

摘　　要：胃癌在我国发病率和死亡率较高,存在发现晚、5年生存率低的特点,手术切除仍然是临床治疗的主要方法。大鼠肉瘤蛋白(Ras)/迅速加速性纤维肉瘤蛋白(Raf)/丝裂原活化的细胞外信号调节激酶(MEK)/细胞外信号调节激酶(ERK)信号通路在调控细胞增殖、转移、凋亡等方面具有非常重要的作用,与胃癌的发生与发展密切相关。近年来,很多学者探索调控Ras/Raf/MEK/ERK信号通路治疗胃癌的作用机制,在信号转导机制研究、靶向抑制剂筛选、中医药治疗等方面取得大量成果,实验验证在胃癌的治疗中干预其信号传递具有良好的效果和应用前景。The incidence and mortality of gastric cancer in China are high,with the characteristics of late detection and low five-year survival rate.Surgical resection is still the main method of clinical treatment.Ras/Raf/MEK/ERK signaling pathway plays a very important role in regulating cell proliferation,metastasis and apoptosis,which is closely related to the development and progression of gastric cancer.In recent years,many scholars have explored the mechanism of regulating Ras/Raf/MEK/ERK pathway in the treatment of gastric cancer,and have made a lot of achievements in signal transduction mechanism research,targeted inhibitor screening,traditional Chinese medicine treatment and other aspects.Experimental validations have shown that mediating Ras/Raf/MEK/ERK pathway signaling has good effects and application prospects in the treatment of gastric cancer.

关 键 词：大鼠肉瘤蛋白/迅速加速性纤维肉瘤蛋白/丝裂原活化的细胞外信号调节激酶/细胞外信号调节激酶(Ras/Raf/MEK/ERK)信号通路 胃癌 基因突变 抑制剂 靶向治疗 中药 研究进展 作用机制 

分 类 号：R273[医药卫生—中西医结合] R735.2[医药卫生—中医肿瘤科]