二甲双胍联合阿卡波糖治疗2型糖尿病的疗效及对糖脂代谢的影响  

Efficacy of metformin combined with acarbose in the treatment of type 2 diabetes and its influence on glucose and lipid metabolism

作　　者：谭章桥 王宗贵 TAN Zhangqiao;WANG Zonggui(The Second People′s Hospital of Xiangtan City,Hunan Province,Xiangtan 411100,China)

机构地区：[1]湖南省湘潭市第二人民医院,411100

出　　处：《临床合理用药杂志》2024年第15期16-19,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的 观察二甲双胍联合阿卡波糖治疗2型糖尿病的疗效及对糖脂代谢的影响。方法 选取2020年2月—2021年2月湘潭市第二人民医院收治的2型糖尿病患者70例为研究对象,按电脑随机法将患者分为阿卡波糖组(n=35)与联合治疗组(n=35)。阿卡波糖组予阿卡波糖,联合治疗组予二甲双胍联合阿卡波糖,2组均持续治疗3个月。比较2组临床疗效,治疗前后氧化应激指标[血清超氧化物歧化酶(SOD)、丙二醛(MDA)]、糖脂代谢指标[糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、总胆固醇(TC)、三酰甘油(TG)]、胰岛功能指标[空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)],不良反应。结果 联合治疗组总有效率高于阿卡波糖组(97.14%vs. 77.14%,χ^(2)=4.590,P=0.032)。治疗3个月后,2组血清SOD水平高于治疗前,血清MDA水平低于治疗前,且联合治疗组高/低于阿卡波糖组(P<0.01);2组HbA1c和FPG、2 hPG、TC、TG水平、HOMA-IR低于治疗前,FINS高于治疗前,且联合治疗组低/高于阿卡波糖组(P<0.01)。联合治疗组与阿卡波糖组不良反应总发生率比较,差异无统计学意义(11.43%vs. 5.71%,χ^(2)=0.182,P=0.669)。结论 二甲双胍联合阿卡波糖治疗2型糖尿病的疗效确切,可有效降低血糖、血脂和氧化应激反应,且联合治疗并未增加不良反应发生风险。Objective To observe the efficacy of metformin combined with acarbose in the treatment of type 2 diabetes and its influence on glycolipid metabolism.Methods Seventy patients with type 2 diabetes who were admitted to the Second People′s Hospital of Xiangtan City from February 2020 to February 2021 were selected as the study subjects.The patients were divided into the acarbose group(n=35)and the combined treatment group(n=35)according to the computer random method.The acarbose group was treated with acarbose,while the combined treatment group was treated with metformin combined with acarbose.Both groups were continuously received treatment for 3 months.Clinical efficacy,oxidative stress indicators(serum SOD,MDA),glucose and lipid metabolism indicators(HbA 1c,FPG,2 hPG,TC,TG),islet function indicators(FINS,HOMA-IR)before and after treatment,incidence of adverse reactions were compared between the two groups.Results The total effective rate of the combined treatment group was higher than that of the acarbose group(97.14%vs.77.14%,χ^(2)=4.590,P=0.032).After 3 months of treatment,serum SOD level in the two groups was higher than before treatment,while serum MDA level was lower than before treatment,and the combined treatment group was higher/lower than the acarbose group(P<0.01);HbA 1c and FPG,2 hPG,TC,TG,HOMA-IR in the two groups were lower than before treatment,FINS was higher than before treatment,and the combined treatment group were lower/higher than the acarbose group(P<0.01).There was no statistically significant difference in the total incidence of adverse reactions between the combined treatment group and the acarbose group(11.43%vs.5.71%,χ^(2)=0.182,P=0.669).Conclusion Metformin combined with acarbose are effective in the treatment of type 2 diabetes,which can effectively reduce blood sugar,blood lipid and oxidative stress,and the combined treatment do not increase the risk of adverse reactions.

关 键 词：2型糖尿病 二甲双胍 阿卡波糖 糖脂代谢 胰岛功能 

分 类 号：R587.1[医药卫生—内分泌] R969[医药卫生—内科学]