中药口服联合艾灸治疗溃疡性结肠炎疗效及安全性的Meta分析  

Efficacy and safety of oral Chinese medicine combined with moxibustion in the treatment of ulcerative colitis: a Meta-analysis

作　　者：张月[1] 张薇[2] ZHANG Yue;ZHANG Wei(Wuhu Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Traditional Chinese Medicine Zhuanshuo Training Base,Anhui Province,Wuhu 241000,China;不详)

机构地区：[1]安徽中医药大学附属芜湖市中医医院专硕研究生培养基地,安徽省芜湖市241000 [2]安徽省芜湖市中医医院,241000

出　　处：《临床合理用药杂志》2024年第15期20-24,28,共6页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的 基于Meta分析评价中药口服联合艾灸治疗溃疡性结肠炎(UC)的临床疗效及安全性。方法 通过计算机检索中国知网、万方数据知识服务平台、维普网和PubMed,收集中药口服联合艾灸治疗UC的临床随机对照试验,检索时间为建库至2022年11月30日。试验组给予中药口服+艾灸治疗或联合常规西药治疗,对照组给予常规西药治疗。由研究人员对收集的文献进行筛选、资料提取,并使用Review Manager 5.4软件进行Meta分析。结果 最终纳入12篇符合标准的文献,共包含1 055例患者,试验组534例,对照组521例。Meta分析结果显示,试验组总有效率高于对照组[OR=3.83,95%CI(2.65,5.53),P<0.000 01]。根据试验组干预方法的不同进行亚组分析:中药口服+艾灸组总有效率高于对照组[OR=3.80,95%CI(2.47,5.85),P<0.000 01];中药口服+艾灸联合常规西药组总有效率高于对照组[OR=3.91,95%CI(1.93,7.91),P=0.000 2]。试验组复发率低于对照组[OR=0.23,95%CI(0.07,0.71),P=0.01]。试验组不良反应发生率低于对照组[OR=0.39,95%CI(0.19,0.78),P=0.007]。结论 中药口服联合艾灸治疗UC可提高总有效率,降低复发率,且不良反应较少。Objective To evaluate the efficacy and safety of oral Chinese medicine combined with moxibustion in the treatment of UC by Meta-analysis-based.Methods A computerized search of CNKI,Wanfang Data,VIP and PubMed was performed to collect clinical randomized controlled trials of oral Chinese medicine combined with moxibustion in the treatment of UC,retrieved from establishment to 2022-11-30.The experimental group was given oral Chinese medicine+moxibustion treatment or combined with conventional western medicine treatment,and the control group was given conventional western medicine treatment.The collected literature was screened,information extracted and Meta-analyzed by the researcher using Review Manager 5.4 software.Results Finally,12 articles were included,including 1055 patients,534 patients in the experimental group and 521 patients in the control group.Meta-analysis showed that,the total effective rate of the experimental group was higher than that of the control group[OR=3.83,95%CI(2.65,5.53),P<0.00001].According to the different intervention methods of the experimental group,subgroup analysis was carried out:the total effective rate of the oral Chinese medicine+moxibustion group was higher than that of the control group[OR=3.80,95%CI(2.47,5.85),P<0.00001];The total effective rate of oral Chinese medicine+moxibustion combined with conventional western medicine group was higher than that of the control group[OR=3.91,95%CI(1.93,7.91),P=0.0002].The recurrence rate of the experimental group was lower than that of the control group[OR=0.23,95%CI(0.07,0.71),P=0.01].The incidence of adverse reactions in the experimental group was lower than that in the control group[OR=0.39,95%CI(0.19,0.78),P=0.007].Conclusion Oral traditional Chinese medicine combined with moxibustion can promote the total effective rate,reduce the recurrence rate and have fewer adverse reactions.

关 键 词：溃疡性结肠炎 中药口服 艾灸 隔药灸 随机对照试验 META分析 

分 类 号：R259[医药卫生—中西医结合]