新斯的明上巨虚穴位注射治疗老年结肠癌术后肠麻痹疗效观察  

Efficacy of Shangjuxu Acupoint Injection with Neostigmine in the Treatment of Postoperative Ileus in Elderly Patients with Colon Cancer

作　　者：刘桂伟[1] 任维聃[1] 李泽钊[1] 杨立胜 董培胜 姜国胜[1] LIU Guiwei;REN Weidan;LI Zezhao;YANG Lisheng;DONG Peisheng;JIANG Guosheng(Cangzhou Central Hospital,Cangzhou,Hebei,China 061000;Cangxian Cui′erzhuang Central Health Center,Cangzhou,Hebei,China 061727)

机构地区：[1]河北省沧州市中心医院,河北沧州061000 [2]河北省沧县崔尔庄中心卫生院,河北沧州061727

出　　处：《中国药业》2024年第11期91-93,共3页China Pharmaceuticals

基　　金：河北省中医药管理局科研计划项目[2021285]。

摘　　要：目的 探讨新斯的明上巨虚穴位注射治疗老年结肠癌术后肠麻痹(POI)的临床疗效。方法 选取河北省沧州市中心医院2020年10月至2022年10月收治的老年结肠癌术后POI患者60例,按随机数字表法分为对照组和研究组,各30例。对照组患者予新斯的明肌肉注射治疗,研究组患者予新斯的明上巨虚穴位注射治疗,两组患者均治疗3 d。结果 研究组总有效率为96.67%,显著高于对照的73.33%(P <0.05)。研究组患者的肠鸣音恢复、首次排便、首次排气、进食、住院的时间均显著低于对照组(P <0.05)。术后1 d,两组患者白细胞介素6(IL-6)及肿瘤坏死因子-α(TNF-α)的表达水平均较术前显著升高(P <0.05);术后3 d,两组患者腹痛、腹胀评分及IL-6,TNF-α的表达水平均较术前显著降低(P <0.05),且研究组均显著低于对照组(P <0.05)。两组患者均未发生不良反应。结论 新斯的明上巨虚穴位注射治疗老年结肠癌术后POI的临床疗效良好,可缓解患者的临床症状,降低炎性因子表达水平,改善肠胃道功能,且安全性好。Objective To investigate the clinical efficacy of Shangjuxu acupoint injection of neostigmine in the treatment of postoperative ileus(POI)in elderly patients with colon cancer.Methods A total of 60 elderly postoperative POI patients with colon cancer admitted to the Cangzhou Central Hospital from October 2020 to October 2022 were randomly divided into the control group and the study group by the random number table method,with 30 cases in each group.The patients in the control group were treated with intramuscular injection of neostigmine,while the patients in the study group were treated with Shangjuxu acupoint injection of neostigmine.Both groups were treated for 3 d.Results The total effective rate in the study group was 96.67%,which was significantly higher than 73.33%in the control group(P<0.05).The recovery time of bowel sounds,first defecation time,first exhaust time,eating time and hospital stay in the study group were significantly shorter than those in the control group(P<0.05).On the 1st day after surgery,the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups significantly increased compared with those before the surgery(P<0.05).On the 3rd day after surgery,the scores of abdominal pain and abdominal distension,and the levels of IL-6 and TNF-αin the two groups significantly decreased compared with those before surgery(P<0.05),and those in the study group were significantly lower than those in the control group(P<0.05).No adverse reactions occurred in the two groups.Conclusion Shangjuxu acupoint injection of neostigmine in the treatment of POI in elderly patients with colon cancer has good clinical efficacy and safety,which can alleviate clinical symptoms,reduce the expression level of inflammatory factors,and improve gastrointestinal function.

关 键 词：新斯的明 上巨虚穴位注射 老年结肠癌 术后肠麻痹 肠胃功能 

分 类 号：R969.4[医药卫生—药理学] R979.1[医药卫生—药学]