用于皮肤温度振荡分析和微血管功能评估的系统设计及应用  

Design and Application of System for Skin Temperature Oscillation Analysis and Microvascular Function Evaluation

作　　者：唐元梁 谭仲威 刘奇 李桂香 TANG Yuanliang;TAN Zhongwei;LIU Qi;LI Guixiang(Instiute of Biological and Medical Engineering,Guangdong Academy of Sciences,Guangzhou Guangdong 510000,China;Guangdong Key Laboratory of Medical Electronic Instruments and Polymer Materials Products,Guangzhou Guangdong 510000,China;Guangdong Engineering Technology Research Center of Traditional Chinese Medicine Smart Diagnosis and Treatment,Guangzhou Guangdong 510000,China)

机构地区：[1]广东省科学院生物与医学工程研究所,广东广州510000 [2]广东省医用电子仪器及高分子材料制品重点实验室,广东广州510000 [3]广东省中医药智慧诊疗工程技术研究中心,广东广州510000

出　　处：《中国医疗设备》2024年第6期1-7,29,共8页China Medical Devices

基　　金：广东省自然科学基金青年提升项目(2024A1515030052);广东省科学院“千名博士(后)计划”引进专项(2020GDASYL-20200103037,2021GDASYL-20210103028);广东省科学院发展专项资金项目(2022GDASZH-2022010110,2023GDASZH-2023010102,2022GDASZH-2022020402-01);广州市科技计划项目基础与应用基础研究专题(2023A04J1846)。

摘　　要：目的设计并实现一种应用于微血管调节功能评估的皮肤温度振荡分析系统。方法由便携式仪器和分析软件所组成的皮肤温度振荡分析系统采用局部热刺激方式诱导人体皮肤产生充血反应,实时采集充血反应前后的皮肤温度变化信号,并基于连续小波变换对皮肤温度振荡幅值进行分析,最终实现对皮肤微血管内皮、神经以及肌源性调节功能的评估。结果利用所研发系统开展的实验研究发现,施加40~41℃热刺激可明显增强皮肤温度波动强度,皮肤温度在内皮(0.0095~0.0200 Hz)、神经(0.02~0.05 Hz)以及肌源性(0.05~0.14 Hz)调节频段的波动幅值分别为无热刺激状态的2.20、4.28和2.77倍。结论本研究验证了热刺激条件下皮肤温度振荡幅值增强的特征,可用于量化分析皮肤微血管运动调节功能。本研究设计和开发的皮肤温度振荡分析系统可为微血管调节功能的评估提供一种有效工具。Objective To design and achieve a skin temperature oscillation analysis system for the evaluation of microvascular regulatory functions.Methods The local thermal stimulation was used by skin temperature oscillation analysis system,composed of portable instruments and analysis software to induce human skin to produce congestion reaction.The skin temperature change signals before and after congestion reaction were collected in real time,and the amplitude of skin temperature oscillation based on continuous wavelet transform was analyzed,and the evaluations of skin microvascular endothelial,nerve and myogenic regulatory functions were realized finally.Results Experimental studies using developed system found that thermal stimulation at 40-41℃significantly enhanced the intensity of skin temperature oscillations.Thefluctuation amplitude of skin temperature in the endothelium(0.0095-0.0200 Hz),neurogenic(0.02-0.05 Hz)and myogenic(0.05-0.14 Hz)frequency bands were 2.20,4.28 and 2.77 times of those without thermal stimulation,respectively.Conclusion This study verifies the enhanced amplitude of skin temperature oscillations under thermal stimulation conditions,which can be used to quantify the functions of skin microvascular movement regulation.The skin temperature oscillation analysis system designed and developed in this paper provides an effective tool for the evaluation of microvascular regulatory functions.

关 键 词：小波分析 血管运动 测温 反应性充血 

分 类 号：R318.6[医药卫生—生物医学工程] R197.39[医药卫生—基础医学]