“机械灌注+”应用于扩大标准供肝移植--肝尽其用  

Machine Perfusion Plus for Extended Criteria Donor Liver Grafts:Making Every Liver Count

作　　者：Zhoucheng Wang Jack Martin Jiongjie Yu Kai Wang Kourosh Saeb-Parsy Xiao Xu 

机构地区：[1]Zhejiang University School of Medicine,Hangzhou 310058,China [2]Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province,Hangzhou 310006,China [3]Department of Surgery,Cambridge University Hospitals&NHS Foundation Trust,Cambridge CB22QQ UK [4]Department of Surgery,University of Cambridge&NIHR Cambridge Biomedical Research Centre,Cambridge CB22QQ,UK [5]Institute of Organ Transplantation,Zhejiang University,Hangzhou 310003,China

出　　处：《Engineering》2024年第1期29-40,共12页工程（英文）

基　　金：the National Key Research and Development Program of China(2021YFA1100500);the Zhejiang University-Cambridge Global Partnership Fund;the National Natural Science Foundation of China(81930016 and 82003248);the Key Research and Development Program of Zhejiang Province(2022C03108);the Projects of Medical and Health Technology Program in Zhejiang Province(WKJZJ-2120).

摘　　要：Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor organs.Extended criteria donor(ECD)liver grafts are increasingly utilized in clinical practice to mitigate this challenge.However,impaired ischemic tolerance of these grafts jeopardizes organ viability during cold storage.Machine perfusion(MP)was designed to improve organ preservation and reduce posttransplant complications.Nevertheless,it is increasingly evident that MP alone may not preserve ECD grafts optimally.Increasing emphasis has thus been placed on modified MP strategies,including the use of different perfusates,modified perfusion modalities,and different therapeutic interventions.Here,we introduce a novel term,"MP Plus,"denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of ECD grafts.In this review,we summarize the existing and potential modified MP strategies and discuss their advantages in reconditioning different ECD grafts in clinical settings.

关 键 词：Liver transplantation Extended criteria donor Machine perfusion plus Organ shortage 

分 类 号：R65[医药卫生—外科学]