流动注射-串联质谱法分析污水中11种毒品  

Analysis of 11 drugs in wastewater by flow injection-tandem mass spectrometry

作　　者：郑吴淇 宁弘宇 陈昊 黄忠平[2] 范一雷 柯星 ZHENG Wuqi;NING Hongyu;CHEN Hao;HUANG Zhongping;FAN Yilei;KE Xing(Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province,Zhejiang Police College,Hangzhou 310053,China;College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]浙江警察学院浙江省毒品防控技术研究重点实验,杭州310053 [2]浙江工业大学化工学院,杭州310014

出　　处：《分析试验室》2024年第5期705-710,共6页Chinese Journal of Analysis Laboratory

基　　金：浙江省自然科学基金项目(LGC21B050001,LTGC23B050003);国家级大学生创新创业训练计划项目(202311483030)资助。

摘　　要：建立了一种流动注射-串联质谱法(FIA-MS/MS)快速检测污水中11种常见毒品。样品经Oasis MCX固相萃取小柱净化和浓缩后,注入FIA-MS/MS系统进行分析。质谱采用正离子模式扫描,在多反应监测模式(MRM)下,同位素内标法定量。结果表明,11种毒品在0.16~200 ng/L范围内线性关系良好,相关系数r^(2)≥0.9902,检出限(LOD)为0.05~0.53 ng/L,定量限(LOQ)为0.16~1.60 ng/L。11种毒品在低、中、高3种加标浓度下,方法回收率为74.5%~113.7%,日内相对标准偏差(RSD)在1.0%~6.9%之间,日间RSD在2.2%~11%之间。该方法适用于污水样品中毒品的高通量筛查和定量分析。A flow injection tandem mass spectrometry(FIA-MS/MS)method has been developed for the rapid detection of 11 common drugs in wastewater.Samples were purified and concentrated by the Oasis MCX solidphase extraction cartridge,followed by injection into the FIA-MS/MS system.Positive ion scanning mode was used for mass spectrometry,and isotope internal standard method in multiple reaction detection mode(MRM)was employed for quantification.The results showed that all the 11 drugs had good linear relationships in the range of 0.16-200 ng/L,with correlation coefficients of r^(2)≥0.9902.The limits of detection(LODs)and limits of quantification(LOQs)were 0.05-0.53 ng/L and 0.16-1.60 ng/L,respectively.At low,medium,and high spiked concentrations,the recoveries of 11 drugs were 74.5%-113.7%,and the relative standard deviations(RSDs)of intra-day and inter-day were 1.0%-6.9%and 2.2%-11%,respectively.The present work provides a method suitable for high-throughput screening and quantitative analysis of toxic substances in wastewater samples.

关 键 词：流动注射-串联质谱法 污水 毒品检测 高通量检测 

分 类 号：O657.31[理学—分析化学] X832[理学—化学]