帕金森病患者胼胝体受损的扩散张量成像研究  

The Study of Corpus Callosum Damage in Parkinson's Disease by Diffusion Tensor Imaging

作　　者：梁智博 张岗 张锐 陈苗 LIANG Zhi-bo;ZHANG Gang;ZHANG Rui;CHEN Miao(Imaging Department,Hulunbuir People's Hospital,Inner Mongolia 021000,China)

机构地区：[1]呼伦贝尔市人民医院影像科,内蒙古021000

出　　处：《影像技术》2024年第3期25-29,共5页Image Technology

摘　　要：目的:利用磁共振扩散张量序列(DTI)对帕金森病患者胼胝体亚区受损进行研究。方法:将2021年1月至2022年6月在我院诊治的30例帕金森病(PD)患者作为病例组,30例健康志愿者作为对照组。两组均行DTI及3D T1bravo扫描,利用工作站对图像后处理,并将胼胝体分为胼胝体膝部、胼胝体体部及胼胝体压部。分别测量两组胼胝体各亚区的部分各向异性(FA)值,并进行统计分析。结果:PD中晚期患者在胼胝体压部FA值低于对照组、PD早期患者,差异有统计学意义(P<0.05)。对照组、PD早期患者、PD中晚期患者在胼胝体膝部、胼胝体体部FA值比较中差异均无统计学意义(P>0.05)。结论:PD中晚期患者胼胝体压部存在损伤可能。Objective:To study the damage of corpus callosum subregion in patients with Parkinson's disease by using diffusion tensor imaging(DTI).Methods:30 Parkinson's disease(PD)patients who were diagnosed and treated in our hospital from January 2021 to June 2022 were selected as the case group,and 30 healthy volunteers were selected as the control group.Both groups underwent DTI and 3D T1bravo scans,and the images were post-processed using a workstation.The corpus callosum was divided into genu of corpus callosum,corpus callosum body,and splenium of corpus callosum.Measured the fractional anisotropy(FA)values of each subregion of the corpus callosum in two groups and conducted statistical analysis.Results:The FA value of Splenium of the corpus callosum in patients with middle and late PD was lower than that in the control group and patients with early PD(P<0.05).There were no significant differences in FA values of genu of corpus callosum,corpus callosum body among the control group,patients with early PD and patients with middle and late PD(P>0.05).Conclusion:The splenium of the corpus callosum may be damaged in PD patients.

关 键 词：帕金森病 胼胝体 磁共振弥散张量成像 部分各向异性 

分 类 号：R445.2[医药卫生—影像医学与核医学]