多胺代谢在调控肿瘤血管生成中作用机制的研究进展  

Research progress of polyamine metabolism in functional regulating tumor angiogenesis

作　　者：李妍芸 曾今诚 梁艳芳 LI Yan-yun;ZENG Jin-cheng;LIANG Yan-fang(.Shantou Health School,Shantou 51500,China;Dongguan Key Labora tory of Medical Bioactive Molecular Developmental and Translational Research,Guangdong Medical University,Dongguan 523808,China;Department of Pathology,Marina Bay Central Hospital of Dongguan,Dongguan 523905,China)

机构地区：[1]汕头市卫生学校,广东汕头515000 [2]广东医科大学东莞市医学活性分子开发与转化重点实验室,广东东莞523808 [3]东莞市滨海湾中心医院病理科,广东东莞523905

出　　处：《广东医科大学学报》2024年第2期219-223,共5页Journal of Guangdong Medical University

基　　金：东莞市社会发展科技项目(20211800904532);广东省基础与应用基础研究基金项目(2021B1515140066)。

摘　　要：多胺(PA)是普遍存在于动植物所有组织和细胞类型中的脂族聚阳离子,与肿瘤的血管生成密切相关。该文就多胺代谢与肿瘤血管生成的关系及机制的研究进展进行综述,以期为靶向多胺代谢的临床抗肿瘤血管生成治疗提供新的理论依据。Polyamines are aliphatic polymeric cations commonly present in all tissues and cell types of animals and plants and polyamine metabolism is closely related to angiogenesis in tumors.This review summarize the research progress on the relationship and mechanism by which polyamine metabolism regulate tumor angiogenesis,providing polyamine metabolism is new target in tumor angiogenesis.

关 键 词：多胺代谢 肿瘤 血管生成 

分 类 号：R392.9[医药卫生—免疫学]