收缩管与拉瓦尔管在液体雾化中的对比研究  

Comparative Study of Converging Nozzle and de Laval Nozzle for Liquid Atomization

作　　者：苏男 梁俊凯 朱勇铮 赵冲 严微微 边鑫 SU Nan;LIANG Junkai;ZHU Yongzheng;ZHAO Chong;YAN Weiwei;BIAN Xin(College of Metrology and Measurement Engineering,China Jiliang University,Hangzhou 310018,Zhejiang,China;Department of Civil Engineering,Zhejiang University,Hangzhou 310027,Zhejiang,China;Hangzhou SHIGUANGJI Intelligent Electronics Technology Limited Company,Hangzhou 310018,Zhejiang,China)

机构地区：[1]中国计量大学计量测试工程学院,浙江杭州310018 [2]浙江大学工程力学系,浙江杭州310027 [3]杭州时光机智能电子科技有限公司,浙江杭州310018

出　　处：《力学季刊》2024年第1期42-57,共16页Chinese Quarterly of Mechanics

基　　金：浙江省教育厅科研资助项目(Y202249443);杭州时光机智能电子科技有限公司资助项目(228101-I22201)。

摘　　要：为探究新型透皮给药方式中不同形状微管对雾化的影响,本文以收缩管和拉瓦尔管为对象展开研究.首先,我们使用相位多普勒粒子分析仪(Phase Doppler Particle Analyzer, PDPA)对经两类微管雾化后的液滴进行速度和粒径分布的测量.然后,为了解管内流动情况,我们利用动态压强传感器对管内气体压强进行了测量,并利用纹影法对管内流动情况进行观察.最后,我们利用高速液滴对皮肤模型进行了喷射试验,其中使用亚甲基蓝和伊文思蓝作为染色试剂,新鲜猪耳作为喷射对象.PDPA实验表明,液滴经拉瓦尔管的雾化比经收缩管的雾化更充分.压强测量结果表明拉瓦尔管内存在激波,进而证明了管内发生过超声速.纹影实验更直观地表明在本研究关注的拉瓦尔管内,气体流动在扩张段形成的不是正激波,而是两道交错的斜激波.皮肤模型喷射实验结果表明雾化后高速液滴穿透了角质层,展示了微喷管在医美行业透皮给药中有潜在的应用价值.该工作为新颖透皮给药方式的进一步研究奠定了基础.To explore the influence of different types of micro-nozzles on the atomization in the transdermal drug delivery,this work takes a converging nozzle and a de Laval nozzle as the research objects.Firstly,the Phase Doppler Particle Analyzer(PDPA)is employed to measure the distributions of velocity and particle size of the droplets from the atomization of the two nozzles.Then,to understand the internal flow conditions,a dynamic pressure sensor is utilized to measure the gas pressure in the nozzle,and the Schlieren imaging is employed to observe the flow in the nozzle.Finally,a skin model is subjected to the impact test of high-speed droplets,where methylene blue solution and Evans blue solution are used as staining agents,and fresh pig ears are adopted as the test objects.The PDPA experiment shows that the atomization of the droplets through the de Laval nozzle is more complete than that through the converging nozzle.The experiment of the internal pressure measurement shows that there is a shock wave in the de Laval nozzle,indicating a supersonic speed at upstream.The Schlieren experimental results directly show that in the de Laval nozzle concerned in this study,the gas flow forms two staggered oblique shock waves,instead of a normal shock wave in the expansion section.The impact test of skin model indicates that the high-speed droplets penetrate through the layer of stratum corneum,which demonstrates the application potential of transdermal delivery of drugs in the aesthetic medicine industry.This work lays the foundation for further investigations of novel means for transdermal drug delivery.

关 键 词：收缩管 拉瓦尔管 雾化 PDPA 纹影法 

分 类 号：O35[理学—流体力学]