mRNA疫苗在动物传染病中的研究进展及应用  

mRNA Vaccines:Research Progress and Applications in Animal Infectious Diseases

作　　者：翟崇凯 毛福超 田文静 王聪慧 王迎鲜 张贺伟 ZHAI Chongkai;MAO Fuchao;TIAN Wenjing;WANG Conghui;WANG Yingxian;ZHANG Hewei(Animal Diseases and Public Health Engineering Research Center of Henan Province,Luoyang 471003,China;The Geographical Indication Medicines and Life Health Engineering Research Center of Henan Province,Luoyang 471003,China;Luoyang Key Laboratory of Diagnosis and Immunoprophylaxis of Animal Viral Diseases,Luoyang 471003,China;College of Food and Drugs,Luoyang Polytechnic,Luoyang 471003,China;Department of Mechanical and Electrical Engineering,Luoyang Polytechnic,Luoyang 471003,China)

机构地区：[1]河南省动物疫病与公共卫生工程研究中心,河南洛阳471003 [2]河南省地标药材与生命健康工程研究中心,河南洛阳471003 [3]洛阳市动物病毒病诊断与免疫预防重点实验室,河南洛阳471003 [4]洛阳职业技术学院食品与药品学院,河南洛阳471003 [5]洛阳职业技术学院机电工程学院,河南洛阳471003

出　　处：《河南农业科学》2024年第5期10-21,共12页Journal of Henan Agricultural Sciences

基　　金：河南省科技攻关项目(232102111050);国家自然科学基金项目(32102640);洛阳市核心技术攻关类公益专项(2202034A)。

摘　　要：与传统疫苗相比,mRNA疫苗具有安全性高、有效性好、研发周期短等特点,使其在传染病的预防和控制方面具有得天独厚的优势。目前,mRNA疫苗在新型冠状病毒(COVID-19)肺炎、流感、埃博拉病毒病、寨卡病毒病等人类疾病的防控中取得了巨大进展,但动物用mRNA疫苗研究尚不深入。因此,开发动物用mRNA疫苗来预防和控制家畜、家禽、野生动物等的传染性疾病,成为动物疫病和公共卫生领域的重要研究方向之一。全面探讨了动物传染病mRNA疫苗的设计、制备、递送系统、应用、优势、挑战以及前景,为研制和开发动物传染病mRNA疫苗提供参考。Compared to traditional approaches,RNA vaccines offer advantages such as high safety,good efficacy,and short development cycle,which makes them have unique advantages in the prevention and control of infectious diseases.Currently,mRNA vaccines have made great progress in the prevention and control of COVID⁃19,influenza,Ebola,Zika and other human diseases,but the research on mRNA vaccines for animals is still not in⁃depth.Therefore,the development of mRNA vaccines for animals to prevent and control infectious diseases in livestock,poultry,and wild animals has become one of the important research directions in the field of animal diseases and public health.This review comprehensively discusses the design,preparation,delivery system,application,advantages,challenges and prospects of mRNA vaccines against animal infectious diseases,to provide valuable insights for the development and research of future animal mRNA vaccines.

关 键 词：mRNA疫苗 制备方法 递送系统 免疫机制 动物传染病 

分 类 号：S855[农业科学—临床兽医学]