三七根中2个新成分  

Two new components from root of Panax notoginseng

作　　者：邱子健 黄金莲 保梅芬[1] 魏沣 高慧媛[3] 肖蕾 蔡祥海[1] QIU Zijian;HUANG Jinlian;BAO Meifen;WEI Feng;GAO Huiyuan;XIAO Lei;CAI Xianghai(State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China;Infinitus Co.,Ltd.,Guangzhou 510623,China;School of Traditional Chinese Medicine,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201 [2]无限极(中国)有限公司,广东广州510623 [3]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《中草药》2024年第8期2503-2509,共7页Chinese Traditional and Herbal Drugs

基　　金：云南省产业创新人才项目;中国科学院青年创新促进会项目(2021390);Bualuang ASEAN Chair Professor Research Grand,泰国。

摘　　要：目的进一步研究三七Panax notoginseng干燥根的化学成分。方法采用大孔吸附树脂、硅胶柱、C_(18)反相硅胶柱、Sephadex LH-20凝胶等方法进行成分分离,再依据理化性质和波谱数据对化合物进行结构鉴定。结果从三七干燥根70%乙醇提取物中分离得到11个化合物,包括萜类5个、吡喃酮类3个、呋喃酮类1个、酚苷类1个、其他类1个,分别鉴定为(S)-2-乙基-6-羟基-7-甲氧基苯酞-6-α-L-鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷(1)、△^(8(9))-(Z)-(R)-6-(1-羟基己基)-4-甲氧基-2(5H)-吡喃酮(2)、6-(1-羟基戊基)-4-甲氧基-2(5H)-吡喃酮(3)、6-(1-羟基己基)-5-羟基-3-甲氧基-2(5H)-吡喃酮(4)、4β,10α-香木兰烷二醇(5)、异胡萝卜-6-烯-10β,14-二醇(6)、4(15)-桉叶烯-1β,6α-二醇(7)、两面针碱D(8)、两面针碱C(9)、5-(1-羟基庚基)-3-甲氧基-2(5H)-呋喃酮(10)、3E-5-甲氧基-6-羟基-6-甲基-3-庚烯-2-酮(11)。结论化合物1、2为新化合物,分别命名为三七酚酞苷和三七己烯吡喃酮。化合物6、8、9、11为首次从该植物中分离。Objective To study the chemical constituents of the dried roots of Sanqi[Panax notoginseng(Burk.)F.H.Chen].Methods The separation of the components was carried out using macroporous adsorbent resin,silica gel column,C_(18)reversed-phase silica gel column,and Sephadex LH-20 gel.The structures were identified by physicochemical properties and spectroscopic data.Results Eleven compounds were isolated from 70%ethanol extract of dried roots of P.notoginseng,including five terpenoids,three pyranones,one furanone,one phenolic glycoside and one other.Their structures were identified as(S)-2-ethyl-6-hydroxy-7-methoxyphthalide-6-α-L-rhamnosyl-(1→6)-β-D-glucopyranoside(1),△^(8(9))-(Z)-(R)-6-(1-hydroxyhextyl)-4-methoxy-2(5H)-pyranone(2),6-(1-hydroxypentyl)-4-methoxy-2(5H)-pyranone(3),6-(1-hydroxyhextyl)-5-hydroxy-3-methoxy-2(5H)-pyranone(4),aromadendrane-4β,10α-diol(5),isodauc-6-ene-10β,14-diol(6),1β,6α-dihydroxyeudesma-4(15)-ene(7),nitidumine D(8),nitidumine C(9),5-(1-hydroxyheptyl)-3-methoxy-2(5H)-furanone(10),3E-5-methoxy-6-hydroxy-6-methyl-3-hepten-2-one(11),respectively.Conclusion Compounds 1 and 2 are new compounds and named as panaphthaloside and panapyranone,respectively.Compounds 6,8,9 and 11 were isolated from P.notoginseng for the first time.

关 键 词：三七 酚苷类 吡喃酮类 萜类 三七酚酞苷 三七己烯吡喃酮 异胡萝卜-6-烯-10β 14-二醇 两面针碱D 

分 类 号：R284.1[医药卫生—中药学]