中药调控铁死亡抑制脑缺血再灌注损伤的研究进展  

Research progress on regulating ferroptosis and inhibiting cerebral ischemia reperfusion injury by traditional Chinese medicine

作　　者：赵文举 付海鑫 应春苗 刘向哲[1] ZHAO Wenju;FU Haixin;YING Chunmiao;LIU Xiangzhe(Encephalopathy Center of the First Affiliated Hospital of Henan University of Chinese Medicine,zhengzhou 450046,China;The First Clinical Medical College of Henan University of Chinese Medicine,zhengzhou 450099,China)

机构地区：[1]河南中医药大学第一附属医院脑病中心,河南郑州450046 [2]河南中医药大学第一临床医学院,河南郑州450099

出　　处：《中草药》2024年第8期2812-2819,共8页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划(2022YFC3501103);河南省科技攻关项目(242102311277);河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才(豫卫中医函[2021]8号);河南省“双一流”创建学科中医学科研专项课题(HSRP-DFCTCM-2023-2-18)。

摘　　要：脑缺血再灌注损伤(cerebral ischemia reperfusion injury,CIRI)是缺血性脑卒中的关键病理过程,是临床患者恢复亟须解决的问题。近年来研究发现,铁死亡的病理机制和CIRI密切相关,成为治疗CIRI的新兴靶点。中药治疗卒中具有独特优势,可通过减轻铁超载、减少活性氧产生、激活铁死亡防御通路、调节脂质合成等关键环节抑制铁死亡,减轻CIRI,保护神经功能,促进损伤恢复。通过对中药调控铁死亡治疗CIRI的最新研究进行综述,为中医药治疗CIRI和药物研发提供新思路与新途径。Cerebral ischemia reperfusion injury(CIRI)is the key pathological process of ischemic stroke,which is an urgent problem of clinical patient recovery.Recent studies have revealed that the pathological mechanism of ferroptosis is closely related to CIRI,becoming an emerging target for the treatment of CIRI.Traditional Chinese medicine has unique advantages in treatment of stroke.It can inhibit ferroptosis,reduce CIRI,protect nerve function,and promote the recovery of injury by reducing iron overload,reducing reactive oxygen species production,activating ferroptosis defense pathway,and regulating lipid synthesis.This paper reviews the latest research on the regulation of ferroptosis by traditional Chinese medicine in treatment of CIRI,and provides new ideas and new approaches for treatment of CIRI and drug development with traditional Chinese medicine.

关 键 词：铁死亡 脑缺血再灌注损伤 谷胱甘肽/谷胱甘肽过氧化物酶4信号通路 神经保护 氧化损伤 地黄苷A 黄芪甲苷 黄芩素 大黄酸 

分 类 号：R285[医药卫生—中药学]