基于电阻抗成像分析血流速度和血乳酸浓度电学特性响应  

Electrical Characteristics Response Study of Blood Flow Velocity and Blood Lactate Concentration Based on Electrical Impedance Tomography

作　　者：王芸倩 孙博[1,2] 赵桐 张安[1] 姚佳烽 WANG Yun-Qian;SUN Bo;ZHAO Tong;ZHANG An;YAO Jia-Feng(School of Mechanical and Precision Instrument Engineering,Xi'an University of Technology,Xi'an 710048,China;Department of Mechanical Engineering,Chiba University,Chiba 263-0022,Japan;College of Mechanical&Electrical Engineering,Nanjing University of Aeronautics&Astronautics,Nanjing 210016,China)

机构地区：[1]西安理工大学大学机械与精密仪器工程学院,西安710048 [2]千叶大学工学部机械工学科,日本千叶263-0022 [3]南京航空航天大学机电学院,南京210016

出　　处：《分析化学》2024年第4期531-540,共10页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.62301419,62071224)资助。

摘　　要：运动训练过程中肌肉产生的乳酸通过血液运输到肝脏进行代谢,在此过程中,随着运动强度的提高,肌肉组织产生的乳酸增加,肌肉组织细胞间质乳酸浓度随之升高,引发肌肉疲劳。经皮电刺激神经疗法(TENS)是一种广泛应用于肌肉放松、改善血液外周循环的医疗手段。本研究采用电阻抗层析成像(EIT)方法,通过检测肌肉疲劳的生物标志物血乳酸浓度(C_(bl))的变化引发的组织电学特性响应,可视化呈现TENS对肌肉疲劳的缓解效果。搭建了模拟肌肉组织模型的C_(bl)变化实验平台,测量了C_(bl)变化时模型的空间平均电导率(■)的变化趋势。血流速度与血乳酸的代谢率密切相关,TENS可以加快血流速度,有效减少乳酸在肌肉组织内的堆积,但血流速度过快容易引起继发性心室颤动疾病,威胁人类生命安全。本研究通过搭建的血流速度模拟平台,实时监测了模拟血管附近液体速度(v_(ph))变化引起的■变化,并采用Pearson检验方法验证了模拟肌肉组织模型的C_(bl)和v_(ph)与■之间的相关性。实验结果表明,■与C_(bl)呈正相关(r=0.9113,p<0.001),■与v_(ph)也呈正相关(r=0.9782,p<0.0001)。本研究通过■定量评估了TENS刺激在加快血流速度、加速乳酸代谢以及缓解肌肉疲劳等方面的应用潜力。Lactic acid produced by muscles during exercise training is transported to the liver for metabolism through the bloodstream.In this process,the lactate acid level increases with the increase of exercise intensity,and the concentration of lactate acid in interstitial matrix of muscle tissues increases subsequently,leading to muscle fatigue.Transcutaneous electrical nerve stimulation(TENS)is a widely used medical method for muscle relaxation and improving peripheral blood circulation.To monitor the potential of TENS to alleviate muscle fatigue,this study adopted electrical impedance tomography(EIT)method to visualize the alleviating effect of TENS on muscle fatigue by detecting the tissue electrical characteristics response caused by the changes in blood lactate concentration,a biomarker of muscle fatigue.An experimental platform was thus constructed to mimic the changes of blood lactate concentration(C_(bl))in the muscle tissue model,and to measure the trend of the spatial-mean conductivity(■)in the mimic model during the C_(bl)change.The blood flow velocity was closely related to the metabolic rate of the lactate in the blood.TENS could speed up blood flow and effectively reduced the lactate accumulation in muscle tissue.However,too fast blood flow velocity was prone to cause secondary ventricular fibrillation disease,which threatened the safety of human life.To avoid this threat,a real-time blood flow velocity mimic platform was developed in this study to monitor■the changes caused by the changes in blood flow velocity(v_(ph))in the vicinity of mimic blood vessels.The correlations between C_(bl)vs■,and v_(ph)vs■in the mimic muscle tissue were verified by Pearson test.Pearson correlation analysis results showed a positive correlation between C_(bl)and(r=0.9113,p<0.05),and between v_(ph)and■(r=0.9782,p<0.001).The approach presented here quantitatively assessed the potential of TENS stimulation-induced changes in lactate concentration and blood flow velocity for alleviating muscle fatigue through■.

关 键 词：经皮电刺激神经疗法 电阻抗成像 血流速度 血乳酸浓度 肌肉疲劳缓解 

分 类 号：O657[理学—分析化学] R87[理学—化学]