2019—2023年北京市某区札如病毒聚集性疫情的流行病学和基因特征分析  

Epidemiological and genetic characteristics of acute gastroenteritis outbreaks caused by sapovirus in one district of Beijing,2019-2023

作　　者：荆红波[1] 韦伟 何牧 王彦波[1] 李湛 张赫 赵宇 贾楠 靖灯节 刘盛田[1] 彭涛[1] Jing Hongbo;Wei Wei;He Mu;Wang Yanbo;Li Zhan;Zhang He;Zhao Yu;Jia Nan;Jing Dengjie;Liu Shengtian;Peng Tao(Microbiology laboratory,Shunyi District Center for Disease Control and Prevention,Beijing 101300,China)

机构地区：[1]北京市顺义区疾病预防控制中心微生物检验科,101300

出　　处：《国际病毒学杂志》2024年第2期160-163,共4页International Journal of Virology

基　　金：北京市高层次公共卫生技术人才建设项目(学科骨干-01-026);北京市顺义区卫生健康发展科研专项(Wsjkfzkyzx-2023-y-04)。

摘　　要：目的了解北京市某区札如病毒引起的聚集性疫情的流行病学及基因特征分析,为疫情防控提供技术支撑。方法收集2019—2023年北京市某区急性胃肠炎聚集性疫情流行病学调查资料和病例粪便样本,使用实时荧光PCR对A组轮状病毒、GⅠ组诺如病毒、GⅡ组诺如病毒、札如病毒、肠道腺病毒和星状病毒进行检测,对札如病毒阳性样本进行VP1区的基因测序和系统进化分析。结果29起急性胃肠炎聚集性疫情中检出了札如病毒,阳性检出率为12.66%。疫情在5—6月和11月有两个高峰,场所主要集中在幼儿园和小学。共检出5个基因型,分别为GⅠ.6、GⅠ.1、GⅡ.3、GⅠ.2和GⅠ.3。结论GⅠ.6是北京某区聚集性疫情主要流行优势株,应对其进行持续监测,进一步了解札如病毒的分子流行特征。Objective To analyse the epidemiological characteristics and genetic features of acute gastroenteritis outbreaks caused by sapovirus in a district of Beijing.Methods Epidemiological investigation date and fecal samples of the patients in acute gastroenteritis outbreaks in a district of Beijing from 2019 to 2023 were collected.Rotavirus,GⅠand GⅡnorovirus,sapovirus,enteric adenovirus and astrovirus were identified by quantitative real-time PCR.Partial VP1 gene sequencing and phylogenetic analysis were performed for sapovirus positive samples.Results Sapovirus was detected in 29 outbreaks and the positive detection rate is 12.66%.There were two significant peaks in May to June and November.The outbreaks occurred mainly in kindergartens and primary schools.Five genotypes were detected,including GⅠ.6,GⅠ.1,GⅡ.3,GⅠ.2 and GⅠ.3.Conclusions GⅠ.6 was the predominant genotype of the outbreaks in a district of Beijing.Continuous surveillance should be carried out for further understanding of the molecular epidemiological characteristics of sapovirus.

关 键 词：急性胃肠炎疫情 札如病毒 基因分型 

分 类 号：R512.5[医药卫生—内科学] R181.3[医药卫生—临床医学]