七氟烷与丙泊酚对减重手术患者围术期低氧诱导因子-1α的变化及术后康复的影响  

Effects of sevoflurane and propofol on perioperative HIF-1α levels and postoperative recovery in patients undergoing bariatric surgery

作　　者：段善娥[1] 钟明铸 张清德[1] 彭雪梅[1] DUAN Shan′e;ZHONG Mingzhu;ZHANG Qingde;PENG Xuemei(Department of Anesthesia,the First Affiliated Hospital of Jinan University,Guanzhou 510630,China;不详)

机构地区：[1]暨南大学附属第一医院麻醉科,广州510630 [2]广东医科大学附属医院麻醉科,广东湛江524000

出　　处：《实用医学杂志》2024年第11期1554-1559,共6页The Journal of Practical Medicine

基　　金：广东省医学科研基金资助项目(编号:A2020533)。

摘　　要：目的探讨七氟烷和丙泊酚对减重手术患者围术期低氧诱导因子-1α(HIF-1α)的不同影响及术后康复的影响。方法将40例体质量指数(BMI)≥44 kg/m^(2)的肥胖患者随机分成两组:七氟烷组(n=21)和丙泊酚组(n=19),使用ELISA法定量测定不同时间点人血清中HIF-1α含量,观察患者术后24 h、48 h脐部切口的红肿、疼痛、渗液情况及预后相关指标。结果手术后当天七氟烷组的HIF-1α显著提高,丙泊酚组HIF-1α显著降低,术后七氟烷组患者比丙泊酚组患者使用阿片类镇痛药物次数和种类明显减少。结论与丙泊酚相比,七氟烷更适合肥胖患者减重手术的麻醉维持,可以通过减少术后镇痛药物的消耗量和上调HIF-1α水平促进术后加速康复。Objective This study aimed to investigate the differential effects of sevoflurane and propofol on perioperative HIF-1αlevels and postoperative recovery in patients undergoing bariatric surgery.Methods A total of 40 obese patients(BMI≥44 kg/m^(2))were randomly allocated into two groups:sevoflurane(n=21)group and propofol(n=19)group.The quantitative measurement of HIF-1αlevels in human serum at different time points was conducted using ELISA.The assessment of redness,swelling,pain,exudation,and prognosis-related indicators of the patient's umbilical incision was performed at 24 and 48 hours after surgery.Results On the day following surgery,there was a significant increase in HIF-1αlevels in the sevoflurane group and a significant decrease in the propofol group.The frequency and type of opioid analgesics used in the sevoflurane group were significantly lower than those used in the propofol group after surgery.Conclusions Compared with propofol,sevoflurane is more suitable for maintaining anesthesia in obese patients undergoing bariatric surgery.Sevoflurane can promote enhanced recovery after surgery by reducing postoperative analgesic consumption and upregulating HIF-1αlevels.

关 键 词：七氟烷 丙泊酚 低氧诱导因子-1Α 

分 类 号：R614[医药卫生—麻醉学]