基于“毒热致痈”理论探讨清热消痈止泻汤治疗溃疡性结肠炎(湿热型)临床研究  

Clinical study on Qingre Xiaoyong Zhixie decoction in the treatment of ulcerative colitis(damp-heat type)based on the theory of"toxic heat induced carbuncle"

作　　者：龚枭雄 陈教华 胡晓阳[2] 余绪超 张全辉[2] 陈光华[2] 郭昌 GONG Xiao-xiong;CHEN Jiao-hua;HU Xiao-yang;YU Xu-chao;ZHANG Quan-hui;CHEN Guang-hua;GUO Chang

机构地区：[1]江西中医药大学,江西南昌330006 [2]江西中医药大学附属医院肛肠科,江西南昌330006

出　　处：《中国疗养医学》2024年第7期38-41,共4页Chinese Journal of Convalescent Medicine

基　　金：江西省中医药管理局科技计划课题(2023B0153);江西省(省直单位)老中医药专家学术经验继承项目。

摘　　要：目的观察基于“毒热致痈”理论探讨清热消痈止泻汤治疗溃疡性结肠炎(湿热型)的临床疗效。方法选取江西中医药大学附属医院2020年1月至2023年9月收治的60例溃疡性结肠炎(湿热型)患者,采用随机数字表分为观察组和对照组,每组各30例。对照组给予口服美沙拉嗪肠溶片治疗,观察组在此基础上加用清热消痈止泻汤治疗,疗程均为8周。观察比较两组患者的临床疗效、中医证候评分、内镜下黏膜形态(Barcon)评分、安全性评价及治疗后3个月的复发情况。结果总有效率观察组为93.33%,显著高于对照组的73.33%(P<0.05);在中医证候评分及内镜下黏膜形态(Barcon)评分改善方面,观察组均显著优于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05);随访3个月,观察组复发率显著低于对照组,差异有统计学意义(P<0.05)。结论清热消痈止泻汤治疗溃疡性结肠炎(湿热型)患者,可明显改善临床症状,修复肠黏膜,疗效明显而且安全性高。Objective To observe the clinical effects of Qingre Xiaoyong Zhixie decoction on ulcerative colitis(damp-heat type)based on the theory of"toxic heat induced carbuncle".Methods Sixty patients with ulcerative colitis(damp-heat type)admitted to the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2020 to September 2023 were selected and divided into observation group and control group by a random number table,with 30 cases in each group.The control group was treated with oral Mesalazine Enteric-coated tablets,and the observation group was treated with Qingre Xiaoyong Zhixie decoction on the basis of this treatment.The course of treatment was 8 weeks.The clinical effects,TCM syndrome score,endoscopic mucosal morphology(Barcon)score,safety evaluation and recurrence status 3 months after treatment were observed and compared between the two groups.Results The total effective rate of the observation group was 93.33%,which was significantly higher than that of the control group 73.33%(P<0.05).In terms of TCM syndrome score and endoscopic mucosal morphology(Barcon)score,the observation group was significantly better than the control group(P<0.05).There was no difference of statistical significance in the incidence of adverse reactions between the two groups(P>0.05).After 3 months of follow-up,the recurrence rate of the observation group was significantly lower than that of the control group,with difference of statistical significance(P<0.05).Conclusion Qingre Xiaoyong Zhixie decoction can obviously improve clinical symptoms and repair intestinal mucosa in the treatment of ulcerative colitis(damp-heat type)with obvious efficacy and high safety.

关 键 词：“毒热致痈”理论 清热消痈止泻汤 溃疡性结肠炎 湿热型 

分 类 号：R259[医药卫生—中西医结合]