口服尿素^(14)C所致人体剂量转换系数  

Dose conversion coefficients for humans after oral administration of urea-^(14)C

作　　者：张震 唐光毅 马忠剑[2] 朱卫国[3] 陈飞 ZHANG Zhen;TANG Guangyi;MA Zhongjian;ZHU Weiguo;CHEN Fei(National Center for Occupational Safety and Health,NHC,NHC Key Laboratory for Engineering Control of Dust Hazard,Beijing 102308 China;Institute of High Energy Physics,CAS,Beijing 100049 China;National Institute for Radiological Protection,Chinese Center for Disease Control and Prevention,Beijing 100088 China)

机构地区：[1]国家卫生健康委职业安全卫生研究中心,国家卫生健康委粉尘危害工程防护重点实验室,北京102308 [2]中国科学院高能物理研究所,北京100049 [3]中国疾病预防控制中心辐射防护与核安全医学所,北京100088

出　　处：《中国辐射卫生》2024年第2期153-157,共5页Chinese Journal of Radiological Health

摘　　要：目的计算口服尿素^(14)C情况下,人体各器官受照剂量及其剂量转换系数,为评估中国人摄入尿素^(14)C所致内照射剂量提供简便方案。方法在FLUKA软件中导入中国参考人体素模型,模拟不同器官受到^(14)C内照射时,各个器官的吸收剂量,得到口服尿素^(14)C时的剂量转换系数。结果胃、结肠、膀胱、心脏、肌肉等组织器官的吸收剂量转换系数分别为:阴性情况,0.029、0.029、0.32(0.24)、0.028、0.029;阳性情况,0.079、0.078、0.18(0.15)、0.076、0.080,单位mGy/MBq。待积有效剂量转换系数为:阴性,0.041(0.037);阳性,0.082(0.081),单位mSv/MBq。结论本文得到的剂量转换系数可为评估中国人口服尿素^(14)C药物后的受照剂量提供重要参数。Objective To calculate the absorbed doses and conversion coefficients of various organs in humans after oral administration of urea-^(14)C,and to provide a convenient method for evaluating the internal radiation dose caused by ingestion of urea-^(14)C in Chinese population.Methods The Chinese reference human voxel model was imported into the FLUKA software to simulate the absorbed doses to organs under internal exposure to^(14)C,and to obtain the dose conversion coefficients for oral administration of urea-^(14)C.Results The absorbed dose conversion coefficients for the stomach,colon,bladder,heart,and muscles were 0.029,0.029,0.32(0.24),0.028,and 0.029 mGy/MBq in negative cases,and 0.079,0.078,0.18(0.15),0.076,and 0.080 mGy/MBq in positive cases.The committed effective dose coefficients were 0.041(0.037)mSv/MBq in negative cases and 0.082(0.081)mSv/MBq in positive cases.Conclusion The dose conversion coefficients obtained in this study can provide important parameters for evaluating the absorbed dose to Chinese population after oral administration of urea-^(14)C.

关 键 词：吸收剂量 尿素^(14)C 体素模型 转换系数 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]