放创复合伤动物模型的研究进展  

Research progress on animal models of combined radiation-wound injury

作　　者：郝若林 窦桂芳 孟志云 叶彤 李南熹 朱晓霞 顾若兰 吴卓娜 甘慧 HAO Ruolin;DOU Guifang;MENG Zhiyun;YE Tong;LI Nanxi;ZHU Xiaoxia;GU Ruolan;WU Zhuona;GAN Hui(Department of Pharmaceutical Science,Beijing Institute of Radiation Medicine,Beijing 100850 China)

机构地区：[1]军事科学院军事医学研究院辐射医学研究所,北京100850

出　　处：《中国辐射卫生》2024年第2期209-214,共6页Chinese Journal of Radiological Health

基　　金：后勤科研重点项目(JKBWS22J1023);北京市自然科学基金面上项目(7202148)。

摘　　要：放射损伤合并创伤称为放创复合伤。放创复合伤由于结合放射伤和创伤,具有创口反复溃烂,持久难愈的特点,是难愈性创伤的重点研究对象。动物模型的建立是放创复合伤相关研究的关键环节,合理的动物模型是可靠实验结果的有力保障。本文从辐射类型、动物种类、致伤类型、致伤位置等多方面概述和归纳目前各类放创复合伤动物模型的研究进展,为放创复合伤标准化动物模型的建立、伤情机制研究以及防治功效评估提供科学基础。A combined radiation-wound injury refers to a radiation injury combined with a traumatic wound,with the characteristics of repeated ulceration and a long and difficult healing process,which is a focus in the field of research on difficultto-heal wounds.To research combined radiation-wound injuries,the establishment of animal models is a key part,and appropriate animal models are a guarantee of reliable experimental results.This review summarizes the current research progress on various animal models of combined radiation-wound injuries in terms of radiation types,animal species,and injury types and location,aiming to provide a scientific basis for establishing standardized animal models,studying injury mechanisms,and evaluating prevention and treatment efficacy for combined radiation-wound injuries.

关 键 词：放创复合伤 动物模型 难愈创伤 辐射 

分 类 号：X591[环境科学与工程—环境工程]