不同时机高压氧介入治疗视网膜动脉阻塞的临床疗效分析  

Clinical analysis of hyperbaric oxygen therapy for retinal artery occlusion in the different timing

作　　者：林娜娜 楚金亭[1] 陈梦平[2] 孟姗[1] 杨旭 周伟民 孙世龙 LIN Na-na;CHU Jin-ting;CHEN Meng-ping;MENG Shan;YANG Xu;ZHOU Wei-min;SUN Shi-long(Department of Hyperbaric Oxygen,Zhengzhou Second Hospital,Zhengzhou 450006,China;Department of Ophthalmology,Zhengzhou Second Hospital,Zhengzhou 450006,China;Department of Neurology,Zhengzhou Second Hospital,Zhengzhou 450006,China)

机构地区：[1]郑州市第二人民医院高压氧科,450006 [2]郑州市第二人民医院眼科,450006 [3]郑州市第二人民医院神经内科,450006

出　　处：《中国实用眼科杂志》2020年第1期30-33,38,共5页Chinese Journal of Practical Ophthalmology

基　　金：河南省科技攻关项目(162102310211)。

摘　　要：目的分析不同时机高压氧介入治疗视网膜动脉阻塞的临床疗效。方法回顾性分析我院2018年6月至2019年6月眼科住院治疗的68例视网膜动脉阻塞的患者。分为对照组34例;早干预组(发病24h内介入高压氧治疗)17例;晚干预组(发病24 h后介入高压氧治疗)。观察各组患者治疗前后视力、视野平均敏感度、视网膜动脉充盈时间、黄斑中心凹视网膜神经上皮层厚度的变化及治疗有效率。结果治疗后各组视力、视野平均敏感度均高于治疗前(P<0.05),治疗后早干预组视力、视野平均敏感度大于晚干预组(t_(视力)=2.273,P_(视力)=0.030;t_(MS)=2.42,P_(MS)=0.021)。治疗后各组后黄斑中心凹RNL平均厚度减少值、视网膜动脉平均充盈时间减少值差异具有统计学意义(F_(厚度)=12.65,P_(厚度)<0.05;F_(FT)=16.07,P_(FT)<0.05),治疗后早干预组黄斑中心凹RNL平均厚度减少值、视网膜动脉平均充盈时间减少值大于晚干预组(t_(厚度)=2.718,P_(厚度)=0.010;t_(FT)=3.186,P_(FT)=0.003)。对照组总有效率为61%,早干预组总有效率为82.4%,晚干预组总有效率为71.4%,早干预组有效率高于晚干预组,差异有统计学意义(χ^(2)=4.61,P<0.05)。结论高压氧联合常规治疗视网膜动脉阻塞疗效优于常规治疗,发病时间24 h内介入高压氧治疗效果更佳。Objective To analyze the clinical efficacy of hyperbaric oxygenation in the different timing treatment of retinal artery occlusion.Methods Retrospective analysis of 68 patients with retinal artery occlusion who were treated in our ophthalmology department from June 2018 to June 2019 divided into three groups:the control group;the early intervention group;the late intervention group.there were 34 patients in the control group;there were 17 patients in the early intervention group those were treated by hyperbaric oxygen therapy within 24 hours of onset;there were 17 patients in the late intervention group those were treated by hyperbaric oxygen therapy 24 hours after the onset of onset.The visual acuity,the average sensitivity of the visual field,the filling time of the retinal artery,the thickness of the retinal neuroepithelial layer in the foveal fovea,and the effective rate of treatment were observed in each group of patients.Results After treatment,the average sensitivity of vision and visual field in each group was higher than before treatment(P<0.05),the average sensitivity of visual acuity and visual field in the early intervention group was greater than that in the late intervention group after treatment(t_(vision)=2.273,P_(vision)=0.030;t_(MS)=2.42,P_(MS)=0.021),after treatment,the difference in the average RNL thickness reduction of the foveal fovea and the average retinal artery filling time reduction in each group was statistically significant(F_(thickness)=12.65,P_(thickness)<0.05;F_(FT)=16.07,P_(FT)<0.05),the decrease in average RNL thickness of the macular fovea and the average filling time of retinal artery in the early intervention group were greater than those in the late intervention group after treatment(t_(thickness)=2.718,P_(thickness)=0.010;t_(FT)=3.186,P_(FT)=0.003),The total effective rate of the control group was 61%,the total effective rate of the early intervention group that was higher than that of the late intervention group(71.4%)was 82.4%(χ^(2)=4.61,P<0.05).Conclusions The effect of

关 键 词：不同时机 高压氧 视网膜动脉阻塞 疗效分析 

分 类 号：R47[医药卫生—护理学]