中医热证动物模型构建及评价方式现状研究  

Research Progress on the Construction and Evaluation of Animal Models of TCM Heat Syndrome

作　　者：曹明慧 张学智[1] 叶晖[1] 郭浩[2] 黎巍威[1] CAO Minghui;ZHANG Xuezhi;YE Hui;GUO Hao;LI Weiwei(First Hospital Affiliated to Peking University,Institute of Integrated Traditional Chinese and Western Medicine,Peking University,Beijing 100034,China;Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]北京大学第一医院,北京大学中西医结合研究所,北京100034 [2]中国中医科学院西苑医院基础医学研究所,北京100091

出　　处：《中国中医药图书情报杂志》2024年第3期11-16,共6页Chinese Journal of Library and Information Science for Traditional Chinese Medicine

基　　金：北京市中医药科技发展资金项目(JJ-2020-03);中国中医科学院科技创新工程(CI2021A04602);国家中医药管理局中医传承与创新“百千万”人才工程(岐黄工程)-国家中医药领军人才支撑计划项目(2021年)。

摘　　要：辨证论治是中医的主要特色,“证”体现的是疾病发生发展进程中不同阶段病理的本质。建立对应疾病的证候模型对挖掘证候的本质,探索中医药研究的规范化、客观化、科学化均具有重要价值。“热证”是中医辨证中极具代表性的基础证型,其病证结合动物模型的制备和研发对于药理实验研究、寒热证实质研究及中医病证结合动物模型的研发尤为重要。本文从模型制备方法、客观指标评价等方面对中医热证动物模型的制备现状及研究进展进行相关述评。Syndrome differentiation and treatment is the main feature of TCM.The“syndrome”reflects the essence of pathology at different stages in the occurrence and development of diseases.Establishing a syndrome model for corresponding diseases is of great value in exploring the essence of syndrome and exploring the standardization,objectivity,and scientificity of TCM research.“Heat syndrome”is a highly representative basic syndrome type in TCM,and the preparation and development of animal models combining disease and syndrome are particularly important for pharmacological experimental research,research on the essence of cold and heat syndrome,and the development of animal models combining with TCM disease and syndrome.This article provided a comprehensive review of the current status and research progress in the preparation of animal models for TCM heat syndrome from the perspectives of model preparation methods and objective indicator evaluation.

关 键 词：热证 动物模型 病证结合 述评 

分 类 号：R2-03[医药卫生—中医学]