精密输液器用聚醚砜微滤膜孔径调控研究  

Study on Pore Size Regulation of Polyethersulfone Microfiltration Membrane for Precision Infusion Set

作　　者：陈成亮 朱建东 戴鹏 汪毅 刘炳荣 王甘英 邱彦深 CHEN Chengliang;ZHU Jiandong;DAI Peng;WANG Yi;LIU Bingrong;WANG Ganying;QIU Yanshen(Jiangxi Sanxin Medical Technology Co.,Ltd.,Nanchang 330200,China)

机构地区：[1]江西三鑫医疗科技股份有限公司,江西南昌330200

出　　处：《生物化工》2024年第2期76-82,共7页Biological Chemical Engineering

基　　金：江西省南昌市科技局2019年度科技项目(洪科字〔2019〕243号)。

摘　　要：本文通过正交实验和成膜工艺调控,采用非溶剂致相分离法制备不同孔径的聚醚砜微孔膜,然后将其加工成过滤器,最后再组装成输液器。系统研究铸膜液组成、环境湿度、空气浴时间、凝固浴的组成以及凝固浴的温度对膜孔径、输液器的输液流速和滤除率影响。实验结果表明:聚醚砜质量分数为12.5%,聚乙烯吡咯烷酮质量分数为5.5%,去离子水质量分数为6%,环境相对湿度为60%~80%,空气浴时间为240 s,凝固浴(二甲基乙酰胺/去离子水混合液)中二甲基乙酰胺质量分数为55%,凝固浴温度为50℃。该实验条件下的输液流速为66 mL/min,滤除率为98.2%,孔径为4.774μm,能实现5μm孔径调控。本研究不仅为医用过滤器用滤膜的孔径调控研究提供了有益参考,而且在临床上有助于提高输注液体纯度,减少并发症的发生。In this paper,polyethersulfone microporous membranes with different pore sizes are prepared by non-solvent-based phase separation method through orthogonal experiments and film-forming process modulation,and then processed into filters and finally assembled into infusion devices.The effects of the composition of the casting solution,ambient humidity,air bath time,the composition of the solidification bath and the temperature of the solidification bath on the pore size of the membrane,the infusion flow rate and the filtration rate of the infusion filter are systematically investigated.The experimental results show that:the mass fraction of polyethersulfone is 12.5%,the mass fraction of polyvinylpyrrolidone is 5.5%,the mass fraction of deionized water is 6%,the relative humidity of the environment is 60%~80%,the time of the air bath is 240 s,the mass fraction of dimethylacetamide in the coagulation bath(a mixture of dimethylacetamide/deionized water)is 55%,and the temperature of the coagulation bath is 50℃.Under the experimental conditions,the infusion flow rate is 66 mL/min,the filtration rate is 98.2%,and the pore size is 4.774µm to achieve 5µm pore size regulation.This study provides a useful reference not only for pore size regulation of filter membranes used in medical filters,but also helps to improve the purity of infused fluids and reduce the occurrence of complications in clinical practice.

关 键 词：聚醚砜微孔膜 相转化 正交实验 孔径调控 输液过滤器 

分 类 号：O631[理学—高分子化学]