ICP-AES法测定左乙拉西坦注射液中微量元素含量  

Determination of Trace Elements in Levetiracetam Injection by ICP-AES

作　　者：朱晓蕾 徐晓萍 董耀 ZHU Xiaolei;XU Xiaoping;DONG Yao(Productivity Centre of Jiangsu Province,Nanjing 210001,China)

机构地区：[1]江苏省生产力促进中心,江苏南京210001

出　　处：《生物化工》2024年第2期127-129,共3页Biological Chemical Engineering

摘　　要：目的:建立电感耦合等离子体原子发射光谱法(ICP-AES)测定左乙拉西坦注射液中微量元素硅、硼、铝和钡含量的分析方法。方法:样品经酸化后直接用ICP-AES分析,以硅288.158 nm、硼249.772 nm、铝396.152 nm和钡493.408 nm为检测波长,建立标准方程,考察仪器精密度、样品重复性和回收率。结果:线性范围:硅0.5~5.0 mg/L,硼0.1~1.0 mg/L,铝1.0~10.0 mg/L,钡0.01~0.10 mg/L,线性相关系数均大于0.9995;检出限:硅0.044 mg/L、硼0.006 mg/L、铝0.017 mg/L和钡0.0005 mg/L;加标回收率:硅96.3%~103.1%,硼90.0%~95.0%,铝101.3%~106.0%,钡102.0%~105.0%。结论:该测定方法快速、准确、灵敏度高,适用于药品中包装材料迁移微量元素含量变化的研究。Objective:An inductively coupled plasma atomic emission spectrometry(ICP-AES)method is developed for the determination of silicon,boron,aluminum and barium in levetiracetam injection.Methods:The samples are directly analyzed by ICP-AES after acidification,and the detection wavelengths are 288.158 nm for silicon,249.772 nm for boron,396.152 nm for aluminum and 493.408 nm for barium.Establish standard equations to examine instrument precision,sample repeatability,and recovery.Results:The linear range is as follows:silicon 0.5~5.0 mg/L,boron 0.1~1.0 mg/L,aluminum 1.0~10.0 mg/L,barium 0.01~0.10 mg/L,the linear correlation coefficients are all greater than 0.9995;detection limits:silicon 0.044 mg/L,boron 0.006 mg/L,aluminum 0.017 mg/L and barium 0.0005 mg/L;standard recoveries are 96.3%~103.1%for silicon,90.0%~95.0%for boron,101.3%~106.0%for aluminum,102.0%~105.0%for barium.Conclusion:The method is rapid,accurate,sensitive,and is suitable for the study of the content change of trace elements in drugs form packaging materials.

关 键 词：电感耦合等离子体原子发射光谱法 左乙拉西坦注射液 微量元素 

分 类 号：O657.61[理学—分析化学]