NLR联合白细胞介素-6对于慢阻肺患者急性加重期相对危险性的评价  

Evaluation of NLR Combined with Interleukin-6 on the Relative Risk of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：吴娟[1] 宋文娟 罗明洁 周宏伟[2] WU Juan;SONG Wenjuan;LUO Mingjie;ZHOU Hongwei(Department of Respiratory and Critical Care,Nanxishan Hospital of Guangxi Zhuang Autonomous Region,Guilin,Guangxi Zhuang Autonomous Region,541002 China;Department of Respiratory and Critical Care Medicine,Guangxi Qinzhou Second People′s Hospital,Qinzhou,Guangxi Zhuang Autonomous Region,535000 China)

机构地区：[1]广西壮族自治区南溪山医院呼吸与危重症科,广西桂林541002 [2]广西钦州市第二人民医院呼吸与危重症医学科,广西钦州535000

出　　处：《系统医学》2024年第8期1-4,共4页Systems Medicine

基　　金：钦州市科学研究与技术开发计划项目(20223042)。

摘　　要：目的探究中性粒细胞与淋巴细胞比值(Neutrophil/Lymphocyte Ratio,NLR)联合白细胞介素-6(Interleukin-6,IL-6)对慢性阻塞性肺疾病患者急性加重期(Acute Exacerbation of Chronic Obstructive Pulmonary Disease,AECOPD)相对危险性的预测价值。方法选取2020年1月—2023年12月广西壮族自治区南溪山医院收治的124例慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)患者作为研究对象,根据患者病情是否急性加重分为AECOPD组(78例)和COPD组(46例)。采用多因素Logistic回归分析影响COPD患者急性加重的独立危险因素,并采用受试者工作特征(Receiver Operating Characteristic,ROC)曲线分析预测价值。结果AECOPD组中NLR和IL-6水平明显高于COPD组,第1秒用力呼气容积与用力肺活量的比值明显低于COPD组,差异有统计学意义(P均<0.05)。NLR、IL-6是AECOPD的独立影响因素(P均<0.05)。NLR、IL-6预测AECOPD的曲线下面积分别为0.948(95%CI:0.907~0.988)、0.951(95%CI:0.918~0.985),二者联合预测AECOPD的曲线下面积为0.967。结论NLR与IL-6联合检测在COPD病情发展中有重要参考价值,可以作为AECOPD的预测工具。Objective To investigate the predictive value of neutrophil/lymphocyte ratio(NLR)combined with interleukin-6(IL-6)on the relative risk of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 124 patients with chronic obstructive pulmonary disease(COPD)admitted to Nanxishan Hospital of Guangxi Zhuang Autonomous Region from January 2020 to December 2023 were selected as study objects and were divided into the AECOPD group(78 patients)and the COPD group(46 patients)according to whether they had an acute exacerbation or not.Independent risk factors affecting acute exacerbation of COPD patients were analyzed by multifactorial Logistic regression,and the predictive value was analyzed by receiver operating characteristic(ROC)curve.Results The NLR and IL-6 levels were significantly higher in the AECOPD group than in the COPD group,and the forced expiratory volume in the first second/forced vital capacity levels were significantly lower than in the COPD group,and the differences were statistically significant(all P<0.05).NLR and IL-6 were independent influencing factors for AECOPD(both P<0.05).The area under the curve of NLR and IL-6 for predicting AECOPD was 0.948(95%CI:0.907-0.988)and 0.951(95%CI:0.918-0.985),and the area under the curve of the combination of the two for predicting AECOPD was 0.967.Conclusion The combined detection of NLR and IL-6 has an important reference value in COPD disease progression and can be used as a predictive tool for AECOPD.

关 键 词：中性粒细胞/淋巴细胞 白细胞介素-6 慢性阻塞性肺疾病 

分 类 号：R563[医药卫生—呼吸系统]