Cyclin D1、VEGF联合NLR、PLR水平预测慢性鼻窦炎-鼻息肉术后复发的临床研究  

A Clinical Study of Cyclin D1 and VEGF Combined with NLR and PLR Levels for Predicting Recurrence of Chronic Rhinosinusitis-nasal Polyps after Surgery

作　　者：黄若葵[1] 杜日昌[1] 丁明虹[1] HUANG Ruokui;DU Richang;DING Minghong(Department of Otorhinolaryngology,Shaoguan Yuebei People′s Hospital,Shaoguan,Guangdong Province,512026 China)

机构地区：[1]广东省韶关市粤北人民医院耳鼻咽喉科,广东韶关512026

出　　处：《系统医学》2024年第8期5-7,11,共4页Systems Medicine

基　　金：韶关市科技计划项目(210807094530166)。

摘　　要：目的探究Cyclin D1、血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)表达含量联合中性粒细胞/淋巴细胞比值(Neutrophil-lymphocyte Ratio,NLR)和血小板/淋巴细胞比值(Platelet-lymphocyte Ratio,PLR)水平预测慢性鼻窦炎伴鼻息肉(Chronic Rhinosinusitis with Nasal Polyps,CRSwNP)复发的临床加价值。方法选取广东省韶关市粤北人民医院耳鼻喉科于2021年1月—2022年6月收治的333例CRSwNP患者为研究对象,均行慢性鼻窦炎-鼻息肉术治疗,根据术后复发情况分为复发组(138例)和未复发组(195例),比较两组患者一般资料、Cyclin D1、VEG、NLR、PLR水平,采用受试者工作特征(Receiver Operating Characteristic,ROC)曲线分析Cyclin D1、VEGF联合NLR、PLR水平对CRSwNP者术后1年复发的预测效能。结果两组Cyclin D1、VEGF、NLR、PLR水平对比,差异有统计学意义(P均<0.05)。Logistic回归分析结果显示,CRSwNP患者复发的影响因素包括Cyclin D1、VEGF、NLR、PLR水平(OR=1.521、1.483、1.365、1.403,P均<0.05)。ROC曲线结果显示Cyclin D1、VEGF、NLR、PLR四者联合检测的灵敏度、特异度及曲线下面积均高于单独检测(P均<0.05)。结论Cyclin D1、VEGF、NLR、PLR水平是诱发CRSwNP患者术后复发的相关因素,也是预测CRSwNP患者术后复发的可靠性指标。Objective To explore the clinical value of Cyclin D1,vascular endothelial growth factor(VEGF)expression combined with neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)in predicting the recurrence of chronic rhinosinusitis with nasal polyps(CRSwNP).Methods A total of 333 patients with CRSwNP admitted to the Department of Otorhinolaryngology,Yuebei People′s Hospital,Shaoguan City,Guangdong Province from January 2021 to June 2022 were selected as the research objects.All patients were treated with chronic sinusitis-nasal polyps.According to the postoperative recurrence,they were divided into recurrence group(138 cases)and non-recurrence group(195 cases).The general data,Cyclin D1,VEG,NLR and PLR levels of the two groups were compared.The receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of Cyclin D1,VEGF combined with NLR and PLR levels on the recurrence of CRSwNP at 1 year after operation.Results There were significant differences in the levels of Cyclin D1,VEGF,NLR and PLR between the two groups(all P<0.05).Logistic regression analysis showed that the influencing factors of recurrence in patients with CRSwNP included Cyclin D1,VEGF,NLR and PLR levels(OR=1.521,1.483,1.365,1.403,all P<0.05).ROC curve results showed that the sensitivity,specificity and area under the curve of combined detection of Cyclin D1,VEGF,NLR and PLR were higher than those of single detection(all P<0.05).Conclusion The levels of Cyclin D1,VEGF,NLR and PLR are the relevant factors that induce postoperative recurrence in CRSwNP patients,and they are reliable indicators for predicting postoperative recurrence in CRSwNP patients.

关 键 词：慢性鼻-鼻窦炎伴鼻息肉 术后复发 Cyclin D1 VEGF NLR PLR 

分 类 号：R765[医药卫生—耳鼻咽喉科]