瑞马唑仑联合阿芬太尼在非老年高血压患者内镜下结肠息肉切除术中的应用  

Application of Remimazolam Combined with Alfentanil in Endoscopic Resection of Colon Polyps in Non-Elderly Hypertensive Patients

作　　者：李波 曹金良 LI Bo;CAO Jinliang(Department of Anesthesiology,Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Guang-zhou,Guangdong Province,510800 China)

机构地区：[1]广州市中西医结合医院麻醉科,广东广州510800

出　　处：《系统医学》2024年第8期12-15,共4页Systems Medicine

基　　金：广州花都区课题项目(22-HDWS-058)。

摘　　要：目的研究瑞马唑仑联合阿芬太尼在非老年高血压患者内镜下结肠息肉切除术中的应用效果。方法选取2022年8—12月广州市中西医结合医院行结肠镜下结肠息肉切除术的80例高血压Ⅰ~Ⅱ级非老年患者(其中3例因术中肠道准备不充分而退出研究)为研究对象,根据随机数表法分为两组,PA组(n=39)使用丙泊酚+阿芬太尼进行麻醉,RA组(n=38)使用瑞马唑仑+阿芬太尼进行麻醉。比较两组麻醉情况以及不同时期两组平均动脉压、心率变化情况与不良事件发生情况。结果两组麻醉成功率均为100%。与PA组相比,RA组患者意识消失较慢,苏醒时间更短,麻醉后监测治疗室停留时间更短,差异有统计学意义(P均<0.05)。RA组术中的血流动力学比PA组更稳定,差异有统计学意义(P<0.05)。RA组术中和术后的不良事件发生率5.26%低于PA组,差异有统计学意义(χ^(2)=4.988,P<0.05)。结论在结肠镜下息肉切除术中采取瑞玛唑仑联合阿芬太尼的麻醉效果可达到丙泊酚联合阿芬太尼的麻醉效果,并可为非老年高血压患者提供更高麻醉安全性与舒适性。Objective To study the effect of remimazolam combined with alfentanil in endoscopic resection of colon polyps in non-elderly patients with hypertension.Methods A total of 80 non-elderly patients with gradeⅠ-Ⅱhypertension who underwent colonoscopic polypectomy in Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine from August to December 2022(3 of them withdrew from the study due to inadequate intestinal preparation during the operation)were selected as the study objects and were divided into two groups according to random number table method.The PA group(n=39)was anesthetised with propofol+afentanil.In the RA group(n=38),remazolam and afentanil were used as anesthesia.Anesthesia,mean arterial pressure,heart rate and adverse events were compared between the two groups at different periods.Results The success rate of anesthesia in both groups was 100%.Compared with PA group,patients in RA group had slower loss of consciousness,shorter recovery time and shorter postanesthesia care unit residence time,and the differences were statistically significant(all P<0.05).The hemodynamics of RA group was more stable than PA group,and the difference was statistically significant(P<0.05).The incidence of intraoperative and postoperative adverse events in RA group was 5.26%lower than that in PA group,the difference was statistically significant(χ^(2)=4.988,P<0.05).Conclusion The anesthetic effect of Remimazolam combined with alfentanil in colonoscopic polypectomy can achieve the anesthetic effect of propofol combined with alfentanil,and can provide higher anesthesia safety and comfort for non-elderly hypertensive patients.

关 键 词：瑞马唑仑 阿芬太尼 结肠镜 结肠息肉切除术 高血压 

分 类 号：R614[医药卫生—麻醉学]