丁苯酞软胶囊治疗颈动脉粥样硬化患者作用分析  

Analysis of the Role of Butylphthalide Soft Capsules in Treating Patients with Carotid Atherosclerosis

作　　者：张烁[1] 郭延林[1] 肖贺 ZHANG Shuo;GUO Yanlin;XIAO He(Department of Cerebral Disease,Taian Hospital of Traditional Chinese Medicine,Taian,Shandong Province,271000 China)

机构地区：[1]泰安市中医医院脑病科,山东泰安271000

出　　处：《中外医疗》2024年第11期5-8,共4页China & Foreign Medical Treatment

基　　金：山东省中医药科技面上项目(2021M063)。

摘　　要：目的观察丁苯酞软胶囊治疗颈动脉粥样硬化患者的效果。方法回顾性选取2021年9月—2023年2月泰安市中医医院接收的80例颈动脉粥样硬化患者的临床资料,以治疗方法的不同将患者分为对照组(n=40,阿托伐他汀治疗)和观察组(n=40,加用丁苯酞软胶囊治疗),比较两组治疗的效果。结果观察组的临床总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(χ^(2)=4.507,P<0.05)。治疗前,两组的斑块数量、颈动脉内膜中层厚度(Intima-media Thickness,IMT)以及斑块面积对比,差异无统计学意义(P均>0.05);治疗后,观察组斑块数量、IMT以及斑块面积低于对照组,差异有统计学意义(P均<0.05)。治疗前,两组的血清淀粉样蛋白A(Serum Amyloid A,SAA)、白细胞介素-1β(Interleukin-1β,IL-1β)以及白细胞介素-6(Interleukin-6,IL-6)对比,差异无统计学意义(P均>0.05);治疗后,观察组SAA、IL-1β以及IL-6低于对照组,差异有统计学意义(P均<0.05)。对照组与观察组的不良反应发生率分别为10.00%与7.50%,差异无统计学意义(P>0.05)。结论在阿托伐他汀的基础上加用丁苯酞软胶囊治疗颈动脉粥样硬化的效果较为明显,同时可以减少斑块数量、IMT以及斑块面积,并且降低炎症因子水平,安全性较好。Objective To observe the effect of butylphthalide soft capsule in treating patients with carotid atherosclerosis.Methods Clinical data of 80 cases of carotid atherosclerosis patients received in Tai'an Traditional Chinese Medicine Hospital from September 2021 to February 2023 were retrospectively selected,and the patients were divided into the control group(n=40,atorvastatin treatment)and the observation group(n=40,plus butylphthalein soft capsule treatment)by different treatment method,and the effects of the two groups'treatments were compared.Results The clinical total effective rate of the observation group was 97.50% higher than that of the control group(80.00%),and the difference was statistically significant(χ^(2)=4.507,P<0.05).Before treatment,there were no statistically significant difference in the number of plaques,carotid intima-media thickness(IMT)and plaque area between the two groups(all P>0.05).After treatment,the number of plaques,IMT and plaque area of the observation group were lower than those of the control group,and the differences were statistically significant(all P<0.05).Before treatment,serum amyloid A(SAA),interleukin-1β(IL-1β)and interleukin-6(IL-6)were compared between the two groups,and the differences were not statistically significant(all P>0.05).After treatment,SAA,IL-1β and IL-6 were lower than those in the control group,and the differences were statistically significant(all P<0.05).The incidence rates of adverse reactions in the control group and observation group were 10.00% and 7.50%,respectively,and the difference was not statistically significant(P>0.05).Conclusion The addition of butylphthalide soft capsule to atorvastatin for the treatment of carotid atherosclerosis is more effective,and at the same time,it can improve the number of plaques,IMT,and plaque area,as well as the reduction of inflammatory factors levels,and the safety of better.

关 键 词：丁苯酞软胶囊 颈动脉粥样硬化 斑块面积 炎症因子水平 

分 类 号：R4[医药卫生—临床医学]