中医药干预慢性再生障碍性贫血骨髓造血微环境“土壤学说”的研究进展  

Research Progress on the“Soil Theory”of Traditional Chinese Medicine Intervention in the Bone Marrow Hematopoietic Microenvironment of Chronic Aplastic Anemia

作　　者：于孙婉琪 杨岩 何丹迪 孙岸弢[4] 储全根[1] YU Sunwanqi;YANG Yan;HE Dandi;SUN Antao;CHU Quangen(Anhui University of Chinese Medicine,Hefei 230012,China;Heilongjiang Academy of Chinese Medicine Sciences,Harbin 150036,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China;Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]安徽中医药大学,安徽合肥230012 [2]黑龙江省中医药科学院,黑龙江哈尔滨150036 [3]黑龙江中医药大学,黑龙江哈尔滨150040 [4]中国中医科学院广安门医院,北京100053

出　　处：《中医药学报》2024年第6期116-120,共5页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金项目(81673968);黑龙江中医药大学研究生创新项目(2022yjscx016)。

摘　　要：为深入研究中医药治疗慢性再生障碍性贫血干预骨髓造血微环境损伤的“土壤学说”的疗效机理,本文对近年来发表的治疗慢性再生障碍性贫血有关骨髓微血管密度、骨髓基质细胞相关因子、黏附分子和信号转导通路等方面的报道进行综述,为今后深入拓展中医药治疗慢性再生障碍性贫血对造血微环境的影响和疗效机理的研究提供新的思路。In order to investigate the therapeutic mechanism of traditional Chinese medicine(TCM)in intervening the damage to bone marrow hematopoietic microenvironment in the treatment of chronic aplastic anemia from the perspective of the“soil theory,”we reviewed and evaluated the recent literature on bone marrow microvascular density,bone marrow stromal cell-related factors,adhesion molecules,and signaling pathways related to the treatment of chronic aplastic anemia with TCM.This review provides new insights for further research on the impact and therapeutic mechanism of TCM in the treatment of chronic aplastic anemia on the hematopoietic microenvironment.

关 键 词：中医药 干预 再生障碍性贫血 慢性 骨髓造血微环境 

分 类 号：R259[医药卫生—中西医结合]