住院老年男性慢性病患者肌少症的相关影响因素  

Factors related to sarcopenia in elderly male in patients with chronic diseases

作　　者：陈茜[1] 邹敏 丁毅[1] CHEN Qian;ZOU Min;DING Yi(Department of Geriatrics,Guizhou Provincial People's Hospital,Guiyang 550002,Guizhou,China)

机构地区：[1]贵州省人民医院老年科,贵州贵阳550002

出　　处：《贵州医科大学学报》2024年第5期716-721,共6页Journal of Guizhou Medical University

基　　金：贵州省卫生健康委科学技术基金项目(Gzwjkj2019-1-057)。

摘　　要：目的探讨住院老年男性慢性病患者肌少症的相关因素。方法纳入老年男性慢性病住院患者96例,收集患者的人口学资料[性别、年龄、体质量指数(BMI)、文化程度及生活习惯(吸烟、饮酒史)]、慢性病(高血压病、糖尿病、冠心病、慢性阻塞性肺疾病、中风)和用药种类,收集患者入院后血液检测指标[C反应蛋白(CRP)、血红蛋白(Hb)、总蛋白(TP)、白蛋白(ALB)、前白蛋白(PAB)、空腹血糖(FPG)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿素氮(BUN)、肌酐(Scr)、估算肾小球滤过率(eGFR)],应用微型营养评定精法(MNA-SF)评估营养状况,老年抑郁量表(GDS-15)评估抑郁状态;根据亚洲肌少症工作组肌少症(AWGS)共识,采用双能X线吸收测定仪评估四肢骨骼肌量(ASM)及脂肪量(FM)、电子握力器评估握力、6 m日常步速评估躯体功能,按诊断标准将患者分为肌少症组65例和非肌少症组31例,比较两组患者的临床资料;采用多因素回归分析住院老年男性慢性病患者肌少症的相关因素。结果肌少症与非肌少症组患者比较,年龄、BMI、四肢骨骼肌质量指数(ASMI)、握力、步速、FM、营养评分、抑郁评分、ALB、PAB、Hb、HDL-C及TG/HDL-C比值比较,差异有统计学意义(P<0.05);logistic多因素回归分析结果显示,TG/HDL-C比值、FM、ALB及BMI与住院老年男性慢性病患者发生肌少症有回归关系,差异有统计学意义(P<0.05)。结论TG/HDL-C比值升高、脂肪量高、白蛋白降低及低BMI与住院老年男性慢性病患者肌少症的发生相关,维持良好的营养状态可能有助于减少老年肌少症的发生。Objective To explore the factors related to sarcopenia in elderly male inpatients with chronic diseases.Methods A total of 96 male inpatients with chronic diseases were enrolled.The general clinical data was documented,including gender,age,body mass index(BMI),education level,living habits(smoking history and drinking history),chronic diseases(hypertension,diabetes,coronary heart disease,chronic obstructive pulmonary disease,stroke),and drug types.Fasting blood samples of the patients after admission were collected to detect C reactive protein(CRP),hemoglobin(Hb),total protein(TP),albumin(ALB),prealbumin(PAB),fasting plasma glucose(FPG),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high LDL-C(HDL-C),blood urea nitrogen(BUN),and serum creatinine(Scr).Glomerular filtration rate(eGFR)was estimated.Nutritional status was assessed by Mini-Nutritional Assessment-Short form(MNA-SF).Depressive symptom was evaluated by the 15-item Geriatric Depression Scale(GDS-15).According to the consensus of Asian Working Group for Sarcopenia(AWGS),dual energy X-ray absorptiometry was used to assess skeletal muscle mass(ASM)and fat mass(FM)of four limbs.Electronic grip strength tester was used to evaluate grip strength.Body function was assessed by 6-m daily pace.According to the diagnostic criteria,the patients were divided into sarcopenia(n=65)and non-sarcopenia(n=31)groups.The clinical data were compared between two groups.Multivariate regression analysis was used to analyze the factors related to sarcopenia in elderly male inpatients with chronic diseases.Results There were significant differences in age,BMI,limb ASM index(ASMI),grip strength,walking speed,FM,nutritional score,depression score,ALB,PAB,Hb,HDL-C,and TG/HDL-C ratio between Sarcopenia and non-Sarcopenia groups(P<0.05).Logistic multivariate regression analysis showed that TG/HDL-C ratio,FM,ALB,and BMI had a regression association with the occurrence of sarcopenia in elderly inpatients with chronic diseases(P<0.05).Conclusion Increased TG/HDL-C ratio,high f

关 键 词：慢性病 肌少症 老年 TG/HDL-C比值 影响因素 

分 类 号：R685.4[医药卫生—骨科学]