诱导癌干细胞铁死亡抗结直肠癌的研究进展  

Research progress of inducing ferroptosis of cancer stem cells against colorectal cancer

作　　者：龚莉娜 袁梦玲 程雪莹 徐晨阳 潘俊 陈秋彤 王玲 张自力 郭玫[1] GONG Li-na;YUAN Meng-ling;CHENG Xue-ying;XU Chen-yang;PAN Jun;CHEN Qiu-tong;WANG Ling;ZHANG Zi-li;GUO Mei(School of Nursing,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学护理学院,江苏南京210023

出　　处：《中国药理学通报》2024年第6期1030-1034,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 82305046,82000572);江苏省自然科学基金资助项目(No BK20220467,BK20200840);江苏省高等学校基础科学(自然科学)研究面上项目(No 22KJB310013);南京药学会-常州四药医院药学科研基金(No 2021YX030);江苏省双创计划资助项目(No JSSCBS20220452)。

摘　　要：癌干细胞(cancer stem cell,CSC)是结直肠癌发生、发展、转移和复发过程中的“种子”细胞,靶向杀伤CSC为抗结直肠癌治疗提供了新靶标。铁死亡是由于细胞内Fe 2+异常积累,导致胞内产生大量活性氧(reactive oxygen species,ROS)和脂质过氧化物,进而引起细胞死亡的铁依赖细胞死亡方式。研究表明CSC较非癌干细胞更富集铁离子,这为靶向诱导CSC铁死亡抗结直肠癌提供了崭新视角。该文简述诱导CSC铁死亡抗结直肠癌的研究进展,如靶向调节CSC中SLC7A11表达、螯合CSC溶酶体中的铁、靶向CSC表型可塑性、逆转CSC铁稳态和靶向CSC脂滴代谢等策略,为抗肿瘤治疗提供新思路。Cancer stem cell(CSC)are the“seed”cells in the occurrence,development,metastasis and recurrence of colorectal cancer.Targeted killing of CSC provides a new target for anti-colorectal cancer therapy.Ferroptosis is an iron-dependent cell death mode due to the abnormal accumulation of intracellular iron ions,which results in the massive reactive oxygen species(ROS)and lipid peroxides,leading to cell death.Studies have shown that cancer stem cells are more enriched in iron ions than non-CSC,which provides a new perspective for targeting ferroptosis in cancer stem cells against colorectal cancer.This article reviews the research progress of inducing CSC ferroptosis in the treatment of colorectal cancer,such as targeted regulation of SLC7A11 expression in CSC,chelating iron in CSC lysosomes,targeting CSC phenotypic plasticity,reversing CSC iron homeostasis,and targeting CSC lipid droplet metabolism induce CSC ferroptosis,which provides new ideas for anti-tumor therapy.

关 键 词：癌干细胞 铁死亡 结直肠癌 活性氧 脂质过氧化 铁离子 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学] R329.25[医药卫生—基础医学] R591.1R735.35