幽门螺杆菌碳13阳性与冠状动脉严重钙化的相关性分析  

Helicobacter pylori carbon 13 positive correlate with the severity of coronary calcification in a screening population

作　　者：宋晓华[1] 王娜[1] 褚南疆 王锦纹[2] SONG Xiaohua;WANG Na;CHU Nanjiang;WANG Jinwen(Department of Healthy Management Center,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所健康管理中心,100029 [2]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所,100029

出　　处：《心肺血管病杂志》2024年第5期438-442,共5页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:探讨幽门螺杆菌碳13呼气试验阳性与冠状动脉钙化严重程度的的相关性。方法:连续入选2021年6月至2023年11月,某三甲医院体检中心体检人员,采集体检人群幽门螺杆菌检测结果,共入选485例,平均年龄(56.6±9)岁,其中男性343例(70.3%)。以及冠状动脉CT结果,并根据冠状动脉钙化积分(coronary artery calcium score,CACS)分为两组,分别为严重钙化组(CACS>400,55例)及(CACS≤400,430例)。结果:入选资料完整体检人群485例,其中幽门螺杆菌阳性126例(26.0%),冠状动脉CTA结果显示冠状动脉严重钙化(钙化积分高于400)共55例(11.3%)。严重钙化组平均年龄显著高于CACS≤400人群[(63.5±8.9)vs.(55.6±8.8),P<0.01],严重钙化组吸烟、饮酒比率高于钙化积分<400组,SBP、FBG、LDL-C水平两组差异有统计学意义。不同冠状动脉钙化程度体检人员的幽门螺杆菌阳性率,差异有统计学意义(P<0.05)。严重钙化组碳13水平(9.9±15.2),碳13阳性占41.8%,钙化积分<400组碳(135.5±9.9),13C-UBT阳性占23.8%(P均<0.05)。严重钙化组颈动脉斑块比率显著高于CACS≤400组。HP阳性组冠状动脉严重钙化比率显著高于HP阴性组(18.3%vs.8.9%,P=0.004)。HP阳性组心率相对高、HDL-C水平相对低(P均<0.05)。多因素Logistic分析分析显示:年龄、吸烟、血脂是冠状动脉钙化的危险因素,与幽门螺杆菌阴性相比,幽门螺杆菌阳性者发生冠状动脉严重钙化的风险相对高(OR=2.100,95%CI:1.094~4.029,P=0.026)。结论:校正传统的心血管危险因素后,幽门螺杆菌阳性患者具有相对高的冠状动脉粥样硬化风险。Objective:To investigate the correlation between helicobacter pylori(HP)13C urea breath test positivity and the severity of coronary artery calcification.Methods:Participants were consecutively enrolled from June 2021 to November 2023 at a tertiary hospital's health examination center.A total of 485 individuals were included,with a mean age of(56.6±9)years,including 343 males(70.3%).HP testing results were collected for all participants,along with coronary artery computed tomography(CT)findings.Participants were divided into two groups based on their coronary artery calcium score(CACS):severe calcification group(CACS>400,55 cases)and non-severe calcification group(CACS≤400,430 cases).Results:Among the 485 participants,126(26.0%)tested positive for HP infection.Coronary artery CT angiography(CTA)revealed severe coronary artery calcification(CAC score>400)in 55 cases(11.3%).The severe calcification group had a significantly higher mean age compared to the non-severe calcification group[(63.5±8.9)vs.(55.6±8.8),P<0.01].Smoking and alcohol consumption rates were higher in the severe calcification group,and there were statistically significant differences SBP,fasting blood glucose(FBG),and LDL-C levels between the two groups.The prevalence of HP infection differed significantly among individuals with different degrees of coronary artery calcification(P<0.05).The mean 13C-urea breath test(UBT)value was(9.9±15.2)in the severe calcification group,with 41.8% testing positive,compared to a mean value of(135.5±9.9)and 23.8% positive in the non-severe calcification group(P<0.05).The severe calcification group also had a significantly higher prevalence of carotid artery plaques compared to the non-severe calcification group.Additionally,the prevalence of severe coronary artery calcification was significantly higher in the HP-positive group compared to the HP-negative group(18.3%vs.8.9%,P=0.004).The HP-positive group had relatively higher heart rates and lower levels of HDL-C(P<0.05).Multivariable Logistic analysis showe

关 键 词：冠状动脉钙化 幽门螺杆菌 动脉硬化 

分 类 号：R54[医药卫生—心血管疾病]