先天性心脏病患儿血型及抗体分布研究  

Study on blood group and antibody distribution in children with congenital heart disease

作　　者：侯玉涛 韩建国 常莹[1] 陈楠 车辑[1] HOU Yutao;HAN Jianguo;CHANG Ying;CHEN Nan;CHE Ji(Department of Blood Transfusion,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所输血科,100029

出　　处：《心肺血管病杂志》2024年第5期447-450,468,共5页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:分析先天性心脏病患儿ABO、Rh、MN血型和抗体分布规律,更精准安全的为临床提供血液。方法:收集2023年1月至2023年11月,来我院行先天性心脏病手术患儿病历资料和备血标本,对备血标本进行ABO血型、Rh(C、c、D、E、e抗原)血型、MN血型和抗体筛选检测,抗体筛选阳性患儿进行抗体特异性鉴定。结果:ABO血型分布频率特征为O型(32.1%)>B型(29.2%)>A型(24.9%)>AB型(13.8%),其中O型患儿531例在ABO血型中所占比例最高;Rh血型抗原阳性率为D(99.4%)e(93.9%)C(88.5%)c(62.9%)E(50.5%),Rh D阳性患儿Rh表型分布情况为Ccee(25.5%)CcEe(22.9%)CCee(18.3%)CCEe(16.8%)ccee(5.5%)ccEe(5.1%)CCEE(2.0%)ccEE(0.7%),Rh D阴性患儿最常见的分型是ccee(占比30%);MN血型M抗原阳性率78.4%,N抗原阳性率71.8%,MN血型构成MN(50.2%)MM(28.2%)NN(21.6%);不规则抗体筛查阳性率为1.3%,最常见的是抗-M(64.3%)。结论:临床上先天性心脏病患儿最常见的血型为O型、Rh D阳性Ccee表型、MN型,而抗-M是最常见的不规则抗体。Objective:To analyze the distribution of ABO,Rh,MN blood groups and antibodies in children with congenital heart disease in order to more precisely and safely supply blood for the clinic.Methods:We collected medical records and blood samples of children who underwent operations for congenital heart disease at our hospital between January 2023 and November 2023.The blood samples were tested for ABO blood type,Rh(C,c,D,E,and e antigen)blood type,MN blood type,and antibody screening.Antibody specificity was identified for children with positive antibody screening.Results:The distribution frequency of ABO blood group types was O type(32.1%)>B type(29.2%)>A type(24.9%)>AB type(13.8%).Among the ABO blood groups,531 children with O type accounted for the highest proportion.The distribution frequency of Rh blood group antigens was D(99.4%)>e(93.9%)>C(88.5%)>c(62.9%)>E(50.5%).In children who tested positive for Rh D,the distribution frequency of Rh was Ccee(25.5%)>CcEe(22.9%)>C cEe(18.3%)>CCEe(16.8%)>CCee(5.5%)>ccEe(5.1%)>CCEe(2.0%)>ccEE(0.7%).The redominant RhDnegative phenotype among children was ccee(30%).Within the MN blood group,the positive rate for the M antigen was 78.4%,while the N antigen exhibited a positive rate of 71.8%,the composition of MN blood group was MN(50.2%)>MM(28.2%)>NN(21.6%).The positive rate of irregular antibody screening was 1.3%,and anti-M was the most common in 64.3%.Conclusions:In children with congenital heart disease,the predominant blood groups include O type,Rh-positive Ccee phenotype,and MN blood type.The most prevalent irregular antibody is anti-M.

关 键 词：先天性心脏病 ABO血型 RH血型 MN血型 抗体 

分 类 号：R54[医药卫生—心血管疾病]