虎杖研究进展及质量标志物预测  

Research Progress and Q-marker Prediction Analysis of Traditional Chinese Medicine Polygonum cuspidatum

作　　者：侯淇允 张林林[2,3,4] 郝艳琦 许浚 张铁军[2,3,4] HOU qi-yun;ZHANG Lin-in;HAO Yan-qi;XU Jun;ZHANG Tie-jun(Tianjin University of Chinese Medicine,Tianjin 301617,China;National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine,Tianjin 300462,China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine,Tianjin 300462,China;Heguang Science and Technology of Traditional Chinese Medicine(Tianjin)Co.,Ltd.,Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津药物研究院药物成药性评价与系统转化全国重点实验室,天津300462 [3]天津药物研究院天津市中药质量标志物重点实验室,天津300462 [4]和光中药科技(天津)有限公司,天津300301

出　　处：《中国现代中药》2024年第5期912-926,共15页Modern Chinese Medicine

基　　金：安徽省科技重大专项(202303a07020007)。

摘　　要：虎杖是我国常用的大宗中药材,资源丰富且分布较广,具有广阔的开发利用前景。虎杖中化学成分类型丰富,包括二苯乙烯、醌、黄酮等类化合物,虎杖的药理作用主要体现在抗炎、抗氧化、抗病毒、抗菌、抗癌、肝保护、心血管保护、免疫调节等方面。在对其化学成分、药理作用综述的基础上,根据中药质量标志物(Q-marker)理论,从生源途径、化学成分有效性、化学成分可测性及不同配伍环境几方面对虎杖Q-marker进行预测分析,为明确虎杖的Q-marker和制定科学的质量标准提供参考。Polygonum cuspidatum(P.cuspidatum)is a commonly used bulk traditional Chinese medicine(TCM)in China,with rich resources and wide distribution,and has broad prospects for development and utilization.P.cuspidatum has a wide range of chemical components,including stilbenes,anthraquinones,flavonoids and other compounds.The pharmacological effects of P.cuspidatum are mainly anti-inflammatory,antioxidant,antiviral,antibacterial,anticancer effects,liver protection,cardiovascular protection,immune regulation and so on.Based on the summary of its chemical components and pharmacological effects,and the theory of quality marker(Q-marker)of TCM,the Q-marker components of P.cuspidatum were predicted and analyzed from the aspects of the source of TCM,chemical component effectiveness,chemical component detectability and different compatibility environments,so as to provide a basis for clarifying the Q-marker of P.cuspidatum and formulating scientific quality standards.

关 键 词：虎杖 质量标志物 蒽醌类 二苯乙烯类 质量控制 

分 类 号：R282[医药卫生—中药学]