肥胖儿童臂-踝脉搏波传导速度影响因素分析  

Influencing factors of arm-ankle pulse wave conduction velocity in obese children

作　　者：狄云霏 丁粤粤[3] 徐秋琴[3] 吕海涛[3] 陈临琪[1] 吴海瑛[1] 陈秀丽[1] 史晓燕[4] 陈婷[1,5] DI Yunfei;DING Yueyue;XU Qiuqin;LYU Haitao;CHEN Linqi;WU Haiying;CHEN Xiuli;SHI Xiaoyan;CHEN Ting(Department of Endocrinology and Genetic Metabolism,Children′s Hospital of Soochow University,Suzhou,Jiangsu 215025;Department of Pediatrics,Wuxi Huishan District People′s Hospital,Wuxi,Jiangsu 214187;Department of Cardiology,Children′s Hospital of Soochow University,Suzhou,Jiangsu 215025;Department of Child Health Care,Children′s Hospital of Soochow University,Suzhou,Jiangsu 215025;Department of Pediatrics,the Sixth Hospital of Kunshan,Kunshan,Jiangsu 215300)

机构地区：[1]苏州大学附属儿童医院内分泌遗传代谢科,江苏苏州215025 [2]无锡市惠山区人民医院儿科,江苏无锡214187 [3]苏州大学附属儿童医院心内科,江苏苏州215025 [4]苏州大学附属儿童医院儿童保健科,江苏苏州215025 [5]昆山市第六人民医院儿科,江苏昆山215300

出　　处：《郑州大学学报（医学版）》2024年第3期357-360,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：江苏省卫生健康委员会科研项目(M2021082);苏州大学临床高峰项目(ML13100523)。

摘　　要：目的:探索肥胖儿童臂-踝脉搏波传导速度(baPWV)的改变,并分析其影响因素。方法:选择2021年6月至2022年10月于苏州大学附属儿童医院内分泌遗传代谢科及儿童保健科就诊的94例肥胖儿童和57例体检健康儿童。比较两组BMI、性别、年龄、血尿酸、血脂、空腹血糖和胰岛素、颈动脉内膜中层厚度(cIMT)、baPWV、BMI的Z分数(Z-BMI)、收缩压(SBP)、舒张压(DBP)、稳态模型胰岛素抵抗指数(HOMA-IR)等的差异。比较肥胖儿童中高血压组和正常血压组、青春期组和青春期前组baPWV的差异。采用多重线性回归分析baPWV的影响因素。结果:肥胖儿童的baPWV慢于健康儿童(P=0.036)。肥胖儿童中,高血压组的baPWV快于正常血压组,青春期组快于青春期前组(P<0.05)。多重线性回归分析结果显示DBP和HOMA-IR是肥胖儿童baPWV的影响因素,B(95%CI)为10.959(4.745~17.173)和3.416(0.771~6.061)。结论:肥胖儿童baPWV与血压、HOMA-IR、青春期有关。Aim:To explore alterations in arm-ankle pulse wave conduction velocity(baPWV)in obese children and analyze its influencing factors.Methods:A total of 94 obese children and 57 physically examined healthy children who attended the Department of Endocrinology and Genetic Metabolism and the Department of Child Health of Children′s Hospital of Soochow University,respectively from June 2021 to October 2022 were selected.The differences in BMI,gender,age,blood uric acid,blood lipids,fasting glucose and insulin,carotid intima-media thickness(cIMT),baPWV,Z-score of BMI(Z-BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),homeostasis model of insulin resistance index(HOMA-IR)were compared between the 2 groups.The differences in baPWV between hypertensive and normotensive,pubertal and prepubertal groups in obese children were compared.Multiple linear regression was used to analyze the influencing factors of baPWV.Results:BaPWV was slower in obese children than in healthy children(P=0.036).In obese children,baPWV was faster in the hypertensive group than that in the normotensive group,and faster in the pubertal group than in the prepubertal group(P<0.05).Multiple linear regression analysis showed that DBP and HOMA-IR were influencing factors for baPWV in obese children,with B(95%CI)of 10.959(4.745-17.173)and 3.416(0.771-6.061).Conclusion:BaPWV in obese children is associated with blood pressure,HOMA-IR,and puberty.

关 键 词：肥胖 儿童 动脉硬化 臂-踝脉搏波传导速度 

分 类 号：R725.8[医药卫生—儿科]