Intake of tobacco nitrosamines of smokers in various provinces of China and their cancer risk:A meta-analysis  

作　　者：Xiao Li Zhiwei Ye Jun Wang Pengfei Lin Xiaojin Zhang Shuguang Xie Chao Chen 

机构地区：[1]Research Institute for Environmental Innovation(Suzhou),Tsinghua,Suzhou,Jiangsu 215163,China [2]State Key Joint Laboratory of Environmental Simulation and Pollution Control,School of Environment,Tsinghua University,Beijing 100084,China [3]Shenzhen Key Laboratory of Organic Pollution Prevention and Control,State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology,Shenzhen 518055,China [4]State Key Joint Laboratory of Environmental Simulation and Pollution Control,College of Environmental Science and Engineering,Peking University,Beijing 100871,China

出　　处：《Journal of Environmental Sciences》2024年第7期249-260,共12页环境科学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.22076091);the Key Technology Research and Development Program of Shandong(No.2020CXGC011406);the Natural Science Foundation of Beijing(No.8212029);the joint project of the State Key Joint Laboratory of Environmental Simulation and Pollution Control(No.21L01ESPC)。

摘　　要：Nitrosamines are a class of carcinogens which have been detected widely in food,water,some pharmaceuticals as well as tobacco.The objectives of this paper include reviewing the basic information on tobacco consumption and nitrosamine contents,and assessing the health risks of tobacco nitrosamines exposure to Chinese smokers.We searched the publications in English from“Web of Science”and those in Chinese from the“China National Knowledge Infrastructure”in 2022 and collected 151 literatures with valid information.The content of main nitrosamines in tobacco,including 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone(NNK),N-nitrosonornicotine(NNN),N-nitrosoanatabine(NAT),N-nitrosoanabasine(NAB),total tobacco-specific nitrosamines(TSNA),and N-nitrosodimethylamine(NDMA)were summarized.The information of daily tobacco consumption of smokers in 30 provinces of China was also collected.Then,the intakes of NNN,NNK,NAT,NAB,TSNAs,and NDMA via tobacco smoke were estimated as 1534ng/day,591 ng/day,685 ng/day,81 ng/day,2543 ng/day,and 484 ng/day by adult smokers in30 provinces,respectively.The cancer risk(CR)values for NNN and NNK inhalation intake were further calculated as 1.44×10^(-5)and 1.95×10^(-4).The CR value for NDMA intake via tobacco smoke(inhalation:1.66×10^(-4))indicates that NDMA is similarly dangerous in tobacco smoke when compared with the TSNAs.In China,the CR values caused by average nitrosamines intake via various exposures and their order can be estimated as the following:smoke(3.75×10^(-4))>food(1.74×10^(-4))>drinking water(1.38×10^(-5)).Smokers in China averagely suffer 200%of extra cancer risk caused by nitrosamines in tobacco when compared with non-smokers.

关 键 词：N-nitrosamine TOBACCO Cancer risk Tobacco specific nitrosamines(TSNAs) N-nitrosodimethylamine(NDMA) 

分 类 号：R163[医药卫生—公共卫生与预防医学]