CK-MB对创伤性颅脑损伤患者预后的影响分析  

作　　者：陈江枫 王颖[2] 周杨 

机构地区：[1]浙江中医药大学研究生院,310000 [2]浙江省绍兴市人民医院,312000

出　　处：《浙江临床医学》2024年第5期725-727,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省医药卫生科技计划青年创新项目(2023RC287)。

摘　　要：目的探讨CK-MB对创伤性颅脑损伤患者预后的影响。方法选取2022年1月至2022年11月本院接诊的420例创伤性颅脑损伤患者,根据初诊分为预后良好组(333例)和预后不良组(87例),并收集两组患者血CK-MB值进行比较。应用Logistic二元回归分析方法分析患者预后不良的影响因素,并运用ROC曲线分析CK-MB值在预测患者预后不良情况中的价值。结果预后不良组患者的CK-MB值明显高于预后良好组(P<0.05)。Logistic回归分析显示,CK-MB与颅脑损伤患者预后不良存在相关性(P<0.05)。ROC曲线分析显示,CK-MB预测患者预后不良的AUC为0.773,最佳临界值对应的敏感度、特异度分别为60.9%、88.6%。结论创伤性颅脑损伤患者的CK-MB值水平与预后存在相关性,属于独立危险因素,对预测创伤性颅脑损伤患者预后有重要价值。Objective To investigate the effect of CK-MB index on the prognosis of patients with traumatic brain injury.Methods From January 2022 to November 2022,420 patients with traumatic brain injury diagnosed and treated in Shaoxing People's Hospital were selected as the research objects.Based on the determined prognosis,the individuals were divided into two distinct groups.The first group,consisting of 333 cases,was classified as having a good prognosis.The second group,comprising 87 cases,was categorized as having a poor prognosis.Serum samples CK-MB were collected and compared.Logistic regression analysis,a statistical model,was utilized to examine the various factors that contribute to a poor prognosis.To evaluate the predictive capability of the biomarker CK-MB in identifying poor prognosis,we employed the receiver operating characteristic(ROC)curve analysis.Results CK-MB in poor prognosis group was significantly higher than that in good prognosis group(P<0.05).Logistic regression analysis showed that CK-MB was significantly associated with poor prognosis in patients with craniocerebral injury(P<0.05),OR value:1.017,95%CI:1.003-1.031;ROC curve analysis showed that the AUC of CK-MB in predicting poor prognosis was 0.773,and by the analysis,the sensitivity of CK-MB in predicting poor prognosis was found to be 60.9%,and the specificity to be 88.6%.Conclusion CK-MB is related to prognosis and is independent risk factors,predicting the prognosis of traumatic brain injury patients.

关 键 词：创伤性颅脑损伤 CK-MB 预后 

分 类 号：R651.15[医药卫生—外科学]