基于脑-肠轴探讨半夏秫米汤治疗慢性失眠的疗效  

作　　者：宋成城 陈克龙[1] 吴紫千 李燕[1] 陈凌[1] 

机构地区：[1]浙江中医药大学附属温州市中医院,325000

出　　处：《浙江临床医学》2024年第5期738-739,743,共3页Zhejiang Clinical Medical Journal

基　　金：浙江中医药大学附属医院科研专项基金项目(2022FSYYZZ27,2022FSYYZQ24)。

摘　　要：目的探讨半夏秫米汤治疗慢性失眠的疗效及作用机制。方法选取2022年1月至2023年12月本院就诊的慢性失眠患者60例,随机分为半夏秫米汤治疗组及枣仁安神颗粒对照组,每组各30例。治疗4周后、8周后分别评估两组患者PSQI、AIS评分,在入院后及4周治疗后行多导睡眠监测、血清脑肠肽SP、NPY及5-HT检测,分析两组临床疗效及作用机制。结果在治疗4周及8周随访时,两组PSQI、AIS评分均明显改善(P<0.01),且治疗组PSQI及AIS改善优于对照组(P<0.05);在治疗4周后,治疗组总睡眠时间、入睡潜伏期、觉醒次数及睡眠效率较治疗前均明显改善(P<0.01),且在改善入睡潜伏期、觉醒次数及睡眠效率方面明显优于对照组(P<0.01)。同时治疗组患者脑肠肽SP、NPY及5-HT较治疗前明显改善(P<0.01),在改善SP、NPY方面明显优于对照组(P<0.01);PSQI评分与脑肠肽SP存在正性线性回归关系(P<0.05),与NYP及5-HT存在负性线性回归关系(P<0.01)。结论半夏秫米汤可明显提高慢性失眠患者睡眠质量,改善患者总睡眠时间、入睡潜伏期、觉醒次数及睡眠效率,其机制可能与调整脑肠肽表达有关,值得进一步研究和推广。Objective To explore the clinical efficacy and mechanism of action of Banxia Shumi Tang in the treatment of chronic insomnia.Methods Sixty patients with chronic insomnia were enrolled and randomly divided into a treatment group and a control group.The treatment group was treated with Banxia Shumi Tang,while the control group was treated with Zaoren Anshen Granules.The Pittsburgh Sleep Quality Index(PSQI)and Athens Insomnia Scale(AIS)scores of the two groups of patients were evaluated after admission,4 weeks of treatment,and 8 weeks of treatment.Polysomnography and serum Brain-gut peptide,such as SP,NPY and 5-HT,were performed after admission and 4 weeks of treatment.So as to analyze the clinical efficacy and mechanism of action of the two groups.Results At the follow-up of 4 and 8 weeks of treatment,both groups showed significant improvement in PSQI and AIS scores(P<0.01),and the treatment group showed more significant improvement in PSQI and AIS(P<0.05).After 4 weeks of treatment,the total sleep time,sleep latency,number of awakenings,and sleep efficiency of the treatment group were significantly improved compared to before treatment(P<0.01),and were significantly better than the control group in improving sleep latency,number of awakenings,and sleep efficiency(P<0.01).At the same time,the Brain-gut peptide SP,NPY,and 5-HT of patients in the treatment group were significantly improved compared to before treatment(P<0.01),and were significantly better than the control group in improving SP and NPY(P<0.01).In addition,there was a positive linear regression relationship(P<0.05)between PSQI score and SP,and a negative linear regression relationship(P<0.01)with NYP and 5-HT.Conclusion Banxia Shumi Tang can significantly improve the sleep quality of patients with chronic insomnia,while improving the total sleep time,sleep latency,number of awakenings,and sleep efficiency.Its mechanism may be related to regulating the expression of Brain-gut peptides.This research provides new ideas and reliable basis for the clinical

关 键 词：半夏秫米汤 慢性失眠 脑-肠轴 多导睡眠监测 

分 类 号：R256.23[医药卫生—中医内科学]