体检数据对颈动脉粥样硬化发生风险的预测价值  

Predictive value of physical examination on the risk of carotid arteriosclerosis

作　　者：武艳[1] 高世超 黄耀孟 王春斌 杨雪梅[1] WU Yan;GAO Shichao;HUANG Yaomeng;WANG Chunbin;YANG Xuemei(Center of Clinical Laboratory,the First Hospital of Hebei Medical University,Hebei Province,Shijiazhuang 050031,China;Medical Technology College,Hebei Medical University,Hebei Province,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第一医院检验中心,河北石家庄050031 [2]河北医科大学医学技术学院,河北石家庄050000

出　　处：《中国医药导报》2024年第11期25-28,共4页China Medical Herald

基　　金：河北省医学科学研究课题计划项目(20190433)。

摘　　要：目的探讨体检指标如性别、年龄、血压、血脂等在颈动脉粥样硬化(CAS)风险评估中的价值。方法随机选取2022年1月至2023年1月河北医科大学第一医院体检人群384例,根据颈动脉超声结果分为动脉硬化组(283例)和对照组(101例)。收集入组人群体检数据,分析CAS发生的影响因素,并采用受试者操作特征(ROC)曲线分析体检指标对CAS的诊断效能。结果两组年龄、男性占比、收缩压、舒张压、高血压者占比、体重指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、血尿酸(URIC)比较,差异有统计学意义(P<0.05)。单因素分析结果显示,年龄、男性、收缩压、舒张压、BMI、TC、TG、LDL-C、FBG、URIC均为CAS的风险因素(P<0.05)。多因素logistic回归分析结果显示,年龄、收缩压、LDL-C、FBG和URIC为CAS发生的独立危险因素(OR=2.415、3.409、3.027、1.759、1.287,P<0.05)。年龄、收缩压、LDL-C、FBG、URIC联合诊断动脉硬化的ROC曲线下面积高于各项指标单独检测(P<0.05)。结论年龄、收缩压、LDL-C、FBG和URIC与CAS的发生密切相关,联合检测对CAS有较好的诊断效能。Objective To investigate the value of physical examination indicators such as gender,age,blood pressure,and blood lipids in the risk assessment of carotid arteriosclerosis(CAS).Methods A random sample of 384 healthy individuals who underwent physical examinations at the First Hospital of Hebei Medical University from January 2022 to January 2023 was selected.Based on carotid artery ultrasound results,participants were divided into arteriosclerosis group(283 cases)and control group(101 cases).Data from the enrolled participants were collected,and the influencing factors of CAS occurrence were analyzed.Receiver operating characteristic(ROC)curve analysis was employed to evaluate the diagnostic efficiency of physical examination indicators for CAS.Results There were statistically significant differences in age,percentage of males,systolic blood pressure,diastolic blood pressure,percentage of patients with hypertension,body mass index(BMI),total cholesterol(TC),triglycerides(TG),low density lipoprotein-cholesterol(LDL-C),fasting blood glucose(FBG),and blood uric acid(URIC)between two groups(P<0.05).Univariate regression analysis showed that age,males,systolic blood pressure,diastolic blood pressure,BMI,TC,TG,LDL-C,FBG,and URIC were all risk factors for CAS(P<0.05).Multivariate regression analysis showed that age,systolic blood pressure,LDL-C,FBG,and URIC were independent risk factors of CAS(OR=2.415,3.409,3.027,1.759,1.287,P<0.05).The areas under the ROC curve of the combined diagnosis of age,systolic blood pressure,LDL-C,FBG,and URIC in CAS were higher than those individual tests(P<0.05).Conclusion Age,systolic blood pressure,LDL-C,FBG,and URIC are closely associated with CAS occurrence,and combined detection demonstrates better diagnostic efficiency for CAS.

关 键 词：颈动脉粥样硬化 低密度脂蛋白胆固醇 空腹血糖 尿酸 早期诊断 

分 类 号：R544.1[医药卫生—心血管疾病]