微针联合米诺地尔搽剂治疗男性雄激素性脱发的临床效果  

Clinical effect of microneedle combined with Minoxidil Liniment in the treatment of male with androgenetic alopecia

作　　者：郭慧敏 唐利利[2] GUO Huimin;TANG Lili(Department of Dermatology,Hefei BOE Hospital,Anhui Province,Hefei230000,China;Department of Dermatology,the First Affiliated Hospital of Anhui Medical University,Anhui Province,Hefei230000,China)

机构地区：[1]合肥京东方医院皮肤科,安徽合肥230000 [2]安徽医科大学第一附属医院皮肤科,安徽合肥230000

出　　处：《中国医药导报》2024年第10期59-63,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(82103723)。

摘　　要：目的探究微针联合米诺地尔搽剂治疗男性雄激素性脱发(AGA)的效果及安全性。方法选择2020年6月至2022年10月合肥京东方医院皮肤科就诊的男性AGA患者139例,采用随机数字表法将其分为微针联合米诺地尔搽剂组(47例)、单用米诺地尔搽剂组(46例)和单用微针组(46例),均治疗24周。比较三组临床疗效;比较三组治疗前后血清睾酮(T)、二氢睾酮(DHT)、性激素结合球蛋白(SHBG)、游离睾酮(FT)水平;比较三组治疗前后毛发密度、毛干直径;观察三组不良反应发生情况。结果微针联合米诺地尔搽剂组临床疗效优于单用米诺地尔搽剂组和单用微针组(P<0.05)。治疗后,三组T、DHT、FT水平较治疗前降低,SHBG水平较治疗前增加(P<0.05);微针联合米诺地尔搽剂组T、DHT、FT水平低于单用米诺地尔搽剂组和单用微针组,SHBG水平高于单用米诺地尔搽剂组和单用微针组(P<0.05)。治疗后,三组毛发密度、毛干直径较治疗前增加(P<0.05);微针联合米诺地尔搽剂组毛发密度大于单用米诺地尔搽剂组和单用微针组、毛干直径大于单用米诺地尔搽剂组和单用微针组(P<0.05)。微针联合米诺地尔搽剂组与单用米诺地尔搽剂组和单用微针组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论微针联合米诺地尔治疗男性AGA患者效果确切,改善患者雄性激素水平,增加患者毛发密度与毛干直径,安全性高。Objective To investigate the effect and safety of microneedle combined with Minoxidil Liniment in the treatment of male androgenetic alopecia(AGA).Methods A total of 139 male patients with AGA who visited the Department of Dermatology,Hefei BOE Hospital from June 2020 to October 2022 were selected.They were divided into microneedle combined with Minoxidil Liniment group(47 cases),monotherapy Minoxidil Liniment group(46 cases),and monotherapy microneedle group(46 cases),all were treated for 24 weeks.The clinical effects of three groups were compared;the levels of serum testosterone(T),dihydrotestosterone(DHT),sex hormone binding globulin(SHBG),and free testosterone(FT)were compared among three groups before and after treatment;hair density and hair stem diameter were compared amog three groups before and after treatment;the occurrence of adverse reactions in three groups were observed.Results The clinical effect of microneedle combined with Minoxidil Liniment group was better than that of monotherapy Minoxidil Liniment group and microneedle group(P<0.05).After treatment,the levels of T,DHT,and FT in three groups were lower than those before treatment,while the levels of SHBG were increased than those before treatment(P<0.05);the levels of T,DHT,and FT of microneedle combined with Minoxidil Liniment group were lower than those of monotherapy Minoxidil Liniment group and monotherapy microneedle group,while the level of SHBG was higher than that of monotherapy Minoxidil Liniment group and monotherapy microneedle group alone(P<0.05).After treatment,the hair density and hair shaft diameter of three groups were increased than those before treatment(P<0.05);the hair density of microneedle combined with Minoxidil Liniment group was higher than that of microneedle Minoxidil Liniment group and microneedle microneedle group,and the hair shaft diameter was higher than that of microneedle Minoxidil Liniment group and microneedle microneedle group alone(P<0.05).There were no significant differences in the incidence of adverse r

关 键 词：微针 米诺地尔搽剂 男性 雄激素性脱发 疗效 

分 类 号：R758[医药卫生—皮肤病学与性病学]