高脂血症痰浊阻遏证动物模型评价量表的初步构建思路  

Theoretical Establishment of the Evaluation Scale for Dyslipidemia at an Animal Model in a Turbid Phlegm Stagnation Syndrome

作　　者：张珊 李宁 薛晓琳 陈婧 叶超[3] 葛肖波 于彤 ZHANG Shan;LI Ning;XUE Xiao-lin;CHEN Jing;YE Chao;GE Xiao-bo;YU Tong(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488;Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029;Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100007;Beijing Hospital of Traditional Chinese Medicine,Affiliated to Capital Medical University,Beijing 100010)

机构地区：[1]北京中医药大学中医学院,北京102488 [2]北京中医药大学第三附属医院,北京100029 [3]北京中医药大学东直门医院,北京100007 [4]首都医科大学附属北京中医医院,北京100010

出　　处：《世界中西医结合杂志》2024年第5期1051-1056,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金项目(82004237);中央高校基本科研业务费专项资金资助(2023-JYB-KYPT-08)。

摘　　要：目的 归纳痰浊内涵,确定痰浊阻遏证动物宏观表征,搭建量表理论框架,为高脂血症痰浊阻遏证动物模型的评价提供可借鉴的方法。方法 检索2012年1月1日—2022年7月1日期间《中医基础理论》《中医大辞典》《中药新药临床指导原则》《中医临床诊疗术语·证候部分》等相关著作中痰浊阻遏证的内容及中国知网(CNKI)、万方(Wanfang)和维普(VIP)数据库发表的与痰浊阻遏证动物模型相关的实验文献,归纳痰浊的具体概念及表现,并以此为依据,确定量表基本框架,建立条目池并赋分。结果 高脂血症痰浊阻遏证动物模型评价量表共包括8个维度,5个测量指标以及7个观察指标。结论 引入量表的评价方式,可完善动物模型的评价体系,提高模型评价的稳定性和可靠性,为保证基于动物模型进行证候生物学基础及干预效果研究的同质性奠定基础。Objective To generalize the connotations of phlegm turbidity,preliminarily identify the macroscopic characteristics of turbid phlegm stagnation syndrome sin animal s,construct a theoretical framework for the scale,and provide a referential method for the evaluation of the animal model with dyslipidemia of turbid phlegm stagnation syndrome.Methods This study searched for“Turbid phlegm stagnation syndrome” in relevant works such as Basic Theory of Traditional Chinese Medicine,Encyclopedia of Traditional Chinese Medicine,Clinical Guidelines for New Chinese Medicine,Clinical Terminology of Traditional Chinese Medicine:Syndrome Section and other related literature published between January 1,2012,and July 1,2022.Also,it searched for experimental literature related to animal models of turbid phlegm stagnation syndrome published in databases such as CNKI,Wanfang,and VIP.The specific concepts and manifestations of phlegm were summarized through a search of ancient and modern literature.On this basis,the basic framework of the scale was developed where a pool of entries was created and scores were assigned.Results The evaluation scale of the animal model with dyslipidemia of turbid phlegm stagnation syndrome included eight dimensions,five measurement entries,and seven observation entries.Conclusion The introduction of scale evaluation lays the foundation for the homogeneity of research on the biological basis of the syndrome and its intervention effects based on animal models.

关 键 词：高脂血症 痰浊阻遏证 量表 

分 类 号：R552[医药卫生—血液循环系统疾病] R-332[医药卫生—内科学]