2014—2020年整形烧伤科皮肤软组织感染患者的病原菌特点和耐药性分析  

Analysis of pathogen characteristics and drug resistance of patients with skin and soft tissue infections in plastic and burn department from 2014 to 2020

作　　者：赵旭 张永祥 严向明[3] 张卫红 李占结 ZHAO Xu;ZHANG Yongxiang;YAN Xiangming;ZHANG Weihong;LI Zhanjie(Emergency(Comprehensive Business)Office,Suzhou Center for DiseaseControl and Prevention,Suzhou 215000;President Office,Children's Hospital of Soochow University,Suzhou 215002,China])

机构地区：[1]江苏省人民医院/南京医科大学第一附属医院感染管理处,江苏南京210029 [2]苏州市疾病预防控制中心应急(综合业务)办公室,江苏苏州215000 [3]苏州大学附属儿童医院院长办公室,江苏苏州215002

出　　处：《临床医学研究与实践》2024年第17期29-32,共4页Clinical Research and Practice

基　　金：2022年度国家自然科学基金青年基金培育计划立项项目(No.PY2022017);江苏省医院协会2023年度医院管理创新研究课题(No.JSYGY-3-2023-559);江苏省人民医院/南京医科大学第一附属医院第三期“优秀中青年人才支持计划”培养项目(No.YNRCQN0314)。

摘　　要：目的分析2014—2020年整形烧伤科皮肤软组织感染(SSTI)患者的病原菌特点及其耐药性。方法回顾性分析2014年1月至2020年12月收治的644例SSTI住院患者的临床资料和病原学检验结果。结果共分离976株病原菌,其中革兰氏阳性菌445株,以金黄色葡萄球菌为主要致病菌,该菌对青霉素、红霉素的耐药率较高;革兰氏阴性菌500株,以铜绿假单胞菌为主要致病菌,该菌对氨苄西林舒巴坦、复方磺胺甲噁唑的耐药率较高。SSTI中院内获得性感染以革兰氏阴性菌为主,社区获得性感染以革兰氏阳性菌为主。多重耐药菌(MDRO)以耐甲氧西林金黄色葡萄球菌(MRSA)及耐碳青霉烯类肠杆菌科细菌(CRE)为主。结论整形烧伤科收治的SSTI病原菌种类繁多,耐药性较高,应在药物敏感试验指导下合理用药。Objective To analyze the pathogen characteristics and drug resistance of patients with skin and soft tissue infections(SSTI)in plastic and burn department from 2014 to 2020.Methods The clinical data and etiological test results of 644 patients with SSTI admitted from January 2014 to December 2020 were retrospectively analyzed.Results A total of 976 strains of pathogens were isolated,including 445 strains of Gram-positive bacteria,with Staphylococcus aureus as the main pathogen.The pathogen had a higher drug resistance rate to penicillin and erythromycin.There were 500 strains of Gram-negative bacteria,with Pseudomonas aeruginosa as the main pathogen.The pathogen had a higher drug resistance rate to ampicillin sulbactam and compound sulfamethoxazole.The nosocomial infection in SSTI was mainly Gram-negative bacteria,and the community-acquired infection was mainly Gram-positive bacteria.Multidrug-resistant organism(MDRO)were mainly methicillin-resistant Staphylococcus aureus(MRSA)and carbapenem-resistant Enterobacteriaceae(CRE).Conclusion There are many kinds of SSTI pathogens in the plastic and burn department,and the drug resistance is high.Rational use of drugs should be guided by drug sensitivity test.

关 键 词：整形烧伤科 皮肤软组织感染 病原菌 耐药性 

分 类 号：R632[医药卫生—外科学]