托伐普坦辅助连续血液净化治疗急性左心衰的效果分析  

Effect analysis of continuous blood purification assisted bytolvaptan in the treatment of acute left heart failure

作　　者：王新颖 WANG Xinying(Cardiovascular Intensive Care Unit,Nanyang First People′s Hospital,Nanyang 473003,China)

机构地区：[1]南阳市第一人民医院心血管重症监护室,南阳473003

出　　处：《华夏医学》2024年第2期156-161,共6页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ202100221)。

摘　　要：目的观察托伐普坦辅助联合血液净化治疗急性左心衰的临床效果。方法选取100例急性左心衰患者,按照随机数字表法分为联合组和常规组,每组50例。常规组予以连续血液净化治疗,联合组采用托伐普坦辅助治疗,比较两组治疗前后的电解质、心功能变化情况、治疗后的临床指标及预后情况。结果治疗后,联合组NT-ProBNP低于常规组,血钠水平高于常规组,差异有统计学意义(P<0.05);LVEF高于常规组,LVDD、sPAP均低于常规组(P<0.05);插管时间、ICU停留时间、呼吸支持辅助率、住院时间以及不良事件发生率均低于常规组(P<0.05)。结论托伐普坦辅助连续血液净化治疗急性左心衰能有效改善患者电解质水平并促进心功能康复,对加快患者康复进程、降低不良事件发生风险均有积极意义。Objective To observing the clinical effect of combined therapy with blood purification to treat acute left heart failure.Methods 100 patients with acute left heart failure were selected and randomly divided into the combination group and conventional group using a number table method,with 50 cases in each group.The conventional group were received continuous blood purification treatment,while the combined group were received adjuvant treatment with tolvaptan.The changes in electrolytes and cardiac function before and after treatment,as well as the clinical indicators and prognosis of the two groups of patients were compared.Results After treatment,the combined group had lower levels of NT-ProBNP and higher blood sodium levels than that in the conventional group,and difference was statistically signifcant(P<0.05).In the combined group,LVEF was higher than that in the conventional group,while LVDD and sPAP were lower than that in the conventional group(P<0.05).The intubation time,ICU stay time,respiratory support assistance rate,hospitalization time,and incidence of adverse events in the control group were lower than those in the conventional group(P<0.05).Conclusion The treatment of acute left heart failure with continuous blood purification assisted by tolvaptan can effectively improve patient electrolyte levels and promote cardiac function recovery,which has positive significance in accelerating patient recovery process and reducing the risk of adverse events.

关 键 词：托伐普坦 连续血液净化 急性左心衰 

分 类 号：R563.8[医药卫生—呼吸系统]