达格列净联合常规降糖药物治疗老年2型糖尿病患者的效果  

Effects of Dapagliflozin combined with conventional hypoglycemic drugs in treatment of elderly patients with type 2 diabetes mellitus

作　　者：郭栋娟 GUO Dongjuan(Department of Pharmacy of Xinzheng Tianyou Hospital of Traditional Chinese Medicine,Zhengzhou 451150 Henan,China)

机构地区：[1]新郑天佑中医院药剂科,河南郑州451150

出　　处：《中国民康医学》2024年第11期26-29,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察达格列净联合常规降糖药物治疗老年2型糖尿病(T2DM)患者的效果。方法:选取2021年8月至2022年8月该院收治的92例老年T2DM患者进行前瞻性研究,以随机数字表法将其分为研究组与对照组各46例。对照组给予常规降糖药物(甘精胰岛素+二甲双胍)治疗,研究组在对照组基础上增加达格列净治疗,比较两组临床疗效、血糖指标[糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2 h血糖(2hPG)]水平、胰岛功能指标[胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)]水平、氧化应激指标[超氧化物歧化酶(SOD)、活性氧(ROS)、丙二醛(MDA)]水平及不良反应发生率。结果:研究组治疗总有效率为95.65%(44/46),高于对照组的78.26%(36/46),差异有统计学意义(P<0.05);治疗后,研究组HbA1c、FPG、2hPG水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组HOMA-β水平高于对照组,HOMA-IR水平低于对照组,差异均有统计学意义(P<0.05);治疗后,研究组SOD水平高于对照组,ROS、MDA水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:达格列净联合常规降糖药物治疗老年T2DM患者可提高治疗总有效率,改善胰岛功能指标和氧化应激指标水平,降低血糖指标水平,效果优于单用常规降糖治疗。Objective:To observe effects of Dapagliflozin combined with conventional hypoglycemic drugs in treatment of elderly patients with type 2 diabetes mellitus(T2DM).Methods:A prospective study was conducted on 92 elderly patients with T2DM admitted to the hospital from August 2021 to August 2022.They were divided into study group and control group by using the random number table method,46 cases in each group.The control group was given routine hypoglycemic therapy(Insulin glargine+metformin),while the study group was treated with Dapagliflozin on the basis of that of the control group.The clinical efficacy,the blood glucose indexes[glycosylated hemoglobin(HbA1c),fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG)]levels,the islet function indexes[isletβcell function index(HOMA-β),insulin resistance index(HOMA-IR)]levels,the oxidative stress indexes[superoxide dismutase(SOD),reactive oxygen species(ROS),malondialdehyde(MDA)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.65%(44/46),which was higher than 78.26%(36/46)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of HbA1c,FPG and 2hPG in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of HOMA-βin the study group was higher than that in the control group,the level of HOMA-IR was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of SOD in the study group was higher than that in the control group,the levels of ROS and MDA were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Dapagliflozin combined with conventional hypoglycemic drugs in the treatme

关 键 词：老年2型糖尿病 达格列净 甘精胰岛素 二甲双胍 血糖 胰岛功能 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]