生长激素联合雌激素治疗重度宫腔粘连术后患者的效果  

Effects of Growth hormone combined with Estrogen in treatment of postoperative patients with severe intrauterine adhesions

作　　者：赵学科 李玉萍 ZHAO Xueke;LI Yuping(Department of Gynaecology and Obstetrics of 73^(rd)Army Group Military Hospital,Xiamen 361000 Fujian,China)

机构地区：[1]陆军第七十三集团军医院妇儿科妇科病区,福建厦门361000

出　　处：《中国民康医学》2024年第11期53-56,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察生长激素联合雌激素治疗重度宫腔粘连术后患者的效果。方法:选取2020年7月至2022年10月该院收治的80例重度宫腔粘连术后患者进行前瞻性研究,按照抽签法将其分为对照组和观察组各40例。对照组采用雌激素治疗,观察组在对照组基础上联合生长激素治疗。比较两组临床疗效,治疗前后子宫内膜厚度、炎性指标[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)]水平,再粘连发生率,试孕成功率,以及不良反应发生率。结果:观察组治疗总有效率为85.00%(34/40),高于对照组的65.00%(26/40),差异有统计学意义(P<0.05);治疗后,观察组子宫内膜厚度大于对照组,差异有统计学意义(P<0.05);治疗后,观察组IL-1β、TNF-α、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05);观察组再粘连发生率为10.00%(4/40),低于对照组的30.00%(12/40),差异有统计学意义(P<0.05);观察组试孕成功率为37.50%(15/40),高于对照组的17.50%(7/40),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:生长激素联合雌激素治疗重度宫腔粘连术后患者可提高治疗总有效率和试孕成功率,改善子宫内膜厚度,降低炎性指标水平和再粘连发生率,效果优于单纯雌激素治疗。Objective:To observe effects of Growth hormone combined with Estrogen in treatment of postoperative patients with severe intrauterine adhesions.Methods:A prospective study was conducted on 80 patients with severe intrauterine adhesions admitted to the hospital from July 2020 to October 2023.According to the lottery method,they were divided into control group and observation group,40 cases in each group.The control group was treated with Estrogen,while the observation group was treated with Growth hormone on the basis of that of the control group.The clinical efficacy,the endometrial thickness,the inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)]levels before and after the treatment,the incidence of re-adhesion,the success rate of trial pregnancy,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 85.00%(34/40),which was higher than 65.00%(26/40)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the endometrial thickness of the observation group was greater than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IL-1β,TNF-αand hs-CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of re-adhesion in the observation group was 10.00%(4/40),which was lower than 30.00%(12/40)in the control group,and the difference was statistically significant(P<0.05).The success rate of trial pregnancy in the observation group was 37.50%(15/40),which was higher than 17.50%(7/40)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Growth hormone combined with Estrogen in the treatment of the patients with severe int

关 键 词：重度 宫腔粘连 术后 生长激素 雌激素 子宫内膜厚度 炎性因子 

分 类 号：R711[医药卫生—妇产科学]